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Biochemistry and Genome Biologyゲノム生化学講座

Staffs

  • Professor: Hodaka Fujii
  • Associate Professor: Toshitsugu Fujita
  • Assistant Professor: Takayuki Hata

Outline

The Department was established in 1972. In 2017, Hodaka Fujii, the current chairperson and professor, joined the Department. The members are conducting biochemical analyses of molecular mechanisms of regulation of genomic functions such as transcription and epigenetic regulation.


Current Research Topics

  • I. Biochemical analyses of molecular mechanisms of regulation of genome functions
    • Using the locus-specific chromatin immunoprecipitation (locus-specific ChIP) technology, which enables isolation of specific genomic regions retaining molecular interactions, we are biochemically analyzing molecular mechanisms of regulation of genome functions such as transcription and epigenetic regulation. Examples of research projects include:
    1. Elucidation of molecular mechanisms of lymphocyte differentiation
    2. Elucidation of molecular mechanisms of X chromosome inactivation
    3. Elucidation of molecular mechanisms of oncogenesis by abnormal epigenetic regulation and development of novel epigenetic drugs against those malignancies.
  • II. Development of accurate, simple, and cost-effective methods to detect nucleotide differences
    • Oligoribonucleotide interference-PCR (ORNi-PCR) is a method that enables detection of nucleotide differences in a target DNA in a sequence-specific manner. Using ORNi-PCR, we are developing accurate, simple, and cost-effective methods for following objectives: (1) detection of cancer cells possessing gene mutations, (2) detection of genome-edited cells, (3) high precision analysis of next-generation sequencing such as analysis of bacterial populations by 16S rRNA gene-based microbiome profiling.

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