2002年　2001年　2000年　1999年　1998年　1997年　1996年　1995年

2002年　

（英文）
Takagaki, K., Ishido K., Kakizaki, I., Iwafune, M., and Endo, M.
Carriers for enzymatic attachment of glycosaminoglycan chains to peptide
Biochem. Biophys. Res., Commun.,(2002) 293, 220-4.

Takagaki K., Iwafune M., Kakizaki I., Ishido K., Kato Y., and Endo M.
The cleavage of the xylosyl serine linkage between a core peptide and a glycosaminoglycan chain by cellulases. 
J. Biol. Chem.,(2002) 277, 18397-403.

Ishido,K., Takagaki, K., Iwafune, M., Yoshihara, S., Sasaki, M., and Endo, M.
Enzymatic attachment of glycosaminoglycan chain to peptide using the sugar chain transfer reaction with endo-beta-xylosidase.
J. Biol. Chem., (2002) 277, 11889-95.

Takagaki, K., Munakata, H., Kakizaki, I., Iwafne, M., Itabashi, T., and Endo, M.
Domain structure of chondroitin sulfate E octasaccharides binding to type V collagen.
J Biol Chem.(2002) 277, 8882-9.

Daidouji K., Takagaki K., Yoshihara S., Matsuya H., Sasaki M., and Endo M. 
Neoplastic changes in saccharide sequence of dermatan sulfate chains derived from human colon cancer. 
Dig Dis Sci. (2002) 47, 331-337

2001年

（英文）
Yukawa, M., Takagaki, K., Itabashi, T., Ueyama, K. , Harata, S., and Endo, M. 
Structural varieties of small proteoglycan in human spinal ligament. 
Connective Tissue Research (2001) 42 (3), 209ﾐ22

Majima, M., Takagaki, K., Sudo, S., Yoshihara, S., Kudo, Y., and Yamagishi, S.: 
Effect of proteoglycan on experimental colitis 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001)  221ﾐ224

Takagaki, K., Kakizaki, I., Iwafune, M., Ishido, K. and Endo, M.: 
Enzymatic reconstruction of glycosaminoglycan oligosaccharides 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001) 239ﾐ244

Endo, Y., Funahashi, M., Kakizaki, I., Takagaki, K., Endo, M., and Yokoyama, M.: 
Hyaluronan knockdown extracellular matrix of cultured human skin fibroblasts by use of 4-methylumbelliferone 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands,  (2001) 265ﾐ268

Kakizaki, I., Takagaki, K., Endo, Y., Ikeya, H., Miyoshi, T., Nakane, A., Weigel, P. H. and Endo, M.
Effect of 4-methylumbelliferone on hyaluronan synthesis of Streptococcus equi FM100
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001) 269ﾐ272

Kukidome, J., Kakizaki, I., Takagaki, K., Matsuki, A., Munakata, A., and Endo, M. 
The mechanism of cell death in human cultured colon adenocarcinoma cell line COLO 201 induced by b-D-N-acetylglucosaminyl-p-nitrophenol
Tohoku J. Ex.p Med. (2001) 194, 23ﾐ34

Matsuya, H., Takagaki, K., Yoshihara, S., Ishido, K., Sasaki, M., and Endo, M.
Changes in glycosaminoglycan, galactosyltransferase-I, and sialyltransferase during rat liver regeneration.
Tohoku J. Exp. Med. (2001) 193, 187ﾐ195

Higuchi, T., Tamura, S., Tanaka, K., Takagaki, K., Saito, Y., and Endo, M.
Effects of ATP on regulation of galactosyl-transferase-I activity responsible for synthesis of the linkage region between the core protein and glycosaminoglycan chains of proteoglycans.
Biochem. Cell Biol. (2001) 79, 159-164

Kukidome, J., Kakizaki, I., Takagaki, K., Matsuki, A., Munakata, A., Endo, M.
Studies on sugar chain elongation in cultured human colon adenocarcinoma cells using 4-methylumbelliferyl glycoside derivatives and p-nitrophenyl glycoside derivatives as artificial primers.
Hirosaki Med. J. (2001) 52, 59ﾐ65

 （和文）
エンド-b-キシロシダーゼを用いたグリコサミノグリカン糖鎖の再構築.遠藤正彦, 高垣啓一, 柿崎育子, 石戸圭之輔
季刊科学総説「糖鎖分子の設計と生理機能」,日本化学会編, 学会出版センター48, pp14−32 (2001)

2000年

（英文）
Takagaki, K., Munakata, H., Kakizaki, I., Majima, M., Endo, M.
Enzymatic reconstruction of dermatan sulfate.
Biochem. Biophys. Res. Commun. (2000) 270 (2), 588ﾐ593

Takagaki, K., Munakata, H., Majima, M., Kakizaki, I., Endo, M.
Chimeric glycosaminoglycan oligosaccharides synthesized by enzymatic reconstruction and their use in substrate specificity determination of Streptococcus hyaluronidase.
J. Biochem. (Tokyo) (2000) 127 (4), 695ﾐ702

Matsuki, A., Takagaki, K., Kukidome, J., Endo, M., and Munakata, A.
Analysis of p-nitrophenyl N-Acetyl-a-D-galactosaminide-induced oligosaccharides produced by the cultured human colon adenocarcinoma cell, DLD-1.
Hirosaki Med. J. (2000) 52, 1ﾐ9 

Takagaki, K., and Ishido, K.
Synthesis of chondroitin sulfate oligosaccharides using enzymatic reconstruction.
Trends Glycosci. Glyc. (2000) 12 (67), 295ﾐ306 

Endo, Y., Takagaki, K., Takahashi, G., Kakizaki, I., Funahashi, M., Yokoyama, M., and Endo, M.
Formation of hyaluronic acid-knock-down extracellular matrix using 4-methylumbelliferone.
In Progress in Transplantation, edited by Munakata, A. Elsevier Science B. V., Amsterdam, the Netherlands, (2000) 1ﾐ7

（和文）
培養細胞によりβ-D-キシロシドをプライマーとして合成されたオリゴ糖
高垣啓一、遠藤正彦
生化学（2000）72（10）1263ﾐ1266

1999年

（英文）Takagaki, K., Munakata, H., Majima, M., and Endo, M.
Enzymatic reconstruction of a hybrid glycosaminoglycan containing 6-sulfated, 4-sulfated, and unsulfated N-acetylgalactosamine.
Biochem. Biophys. Res. Commun. (1999) 258, 741ﾐ744 

Munakata, H., Takagaki, K., Majima, M, and Endo, M.
Interaction between collagens and glycosaminoglycans investigated using a surface plasmon resonance biosensor.
Glycobiology (1999) 9 (10), 1023ﾐ1027 

Takagaki, K., Kakizaki, I., and Endo, M
Development of an enzymatic synthesis method for chimeric glycosaminoglycans.
Hirosaki Med. J. (1999) 51 (Suppl.), S49ﾐS53

（和文）
HPAEC-PAD法によるヒアルロン酸オリゴ糖の分離と定量
須藤　晋一郎, 高垣　啓一, 棟方　秀和, 中村　渉, 松谷　英樹, 遠藤　正彦
J. Appl. Glycosci. (応用糖質科学) (1999) 46 (3), 299ﾐ302

1998年

（英文）
Takagaki, K., Munakata, H., Nakamura, W., Matsuya, H., Majima, M., and Endo, M.
Ion-spray mass spectrometry for identification of the nonreducing terminal sugar of glycosaminoglycan.
Glycobiology (1998) 8, 719ﾐ724

Takagaki, K., Tazawa, T., Munakata, H., Nakamura, T., and Endo, M.
Characterization of β-D-xyloside-initiated glycosaminoglycan synthesized by human skin fibroblasts in the presence of tunicamycin.
Glycoconjugate J. (1998), 15, 483ﾐ489

Tazawa, T., Takagaki, K., Matsuya, H., Nakamura, T., Sasaki, M., and Endo, M.
A novel 4-methylumbelliferyl-β-D-xyloside derivative, sulfate-O-3-xylosyl-β1-(4-methylumbelliferone), isolated from culture medium of human skin fibroblasts, and its role in 4-methylumbelliferone-initiated glycosaminoglycan biosynthesis.
Glycobiology (1998) 8, 879ﾐ884

Ono, A., Harata, S., Takagaki, K., and Endo, M.
Proteoglycans in the nucleus pulposus of canine intervertebral disc after chondroitinase ABC treatment.
J. Spin. Disord. (1998) 11, 253ﾐ260

1997年

（英文）
Tanaka, K., Nakamura, T., Takagaki, K., Funahashi, M., Saito, Y., and Endo, M.
Regulation of hyaluronate metabolism by progesterone in cultured skin fibroblasts from the human uterine cervix.
FEBS Lett. (1997) 402, 223ﾐ226

Takagaki, K., Tazawa, T., Munakata, H., Nakamura, T., and Endo, M.
Effect of monensin on the synthesis of β-D-xyloside-induced glycosaminoglycan and its linkage region oligosaccharides in human skin fibroblasts. 
J. Biochem. (1997) 122, 1129ﾐ1132

Yasukochi, T., Fukase, K., Suda, Y., Takagaki, K., Endo, M., and Kusumoto, S.
Enzymatic synthesis of 4-methylumbelliferyl glycosides of trisaccharide, and core tetrasaccharide, Gal(β1-3)Gal(β1-4)Xyl and GlcA(β1-3)Gal(β1-3)Gal(β1-4)Xyl, corresponding to the linkage region of proteoglycans.
Bull. Chem. Soc. Jpn. (1997) 70, 2719ﾐ2725 

Nakamura, T., Funahashi, Takagaki, K., Munakata, H., Tanaka, K,, Saito, Y., and Endo, M.
Effect of 4-methylumbelliferone on cell-free synthesis of hyaluronic acid.
Biochem. Mol. Biol. Int. (1997) 43, 263ﾐ268 

1996年

（英文）
Takagaki, K., Nakamura, T., Shibata, S., Higuchi, T., and Endo, M.
Characterization and biological significance of sialylα2-3galactosylβ1-4xylosylβ1-(4-methylumbelliferone) synthesized in cultured human skin fibroblasts.
 J. Biochem.  (1996) 119, 697ﾐ702

Saitoh, H., Takagaki, K., Nakamura, T., Munakata, A., Yoshida, Y., and Endo, M. 
Characterization of mucin in whole-gut lavage fluid obtained from patients with inflammatory bowel disease.
Dig. Dis. Sci. (1996) 41, 1768ﾐ1774 

Nakamura, T., Takagaki, K., and Endo, M.
New hyaluronan-degrading enzymes.
Connective Tissue (1996) 28, 15ﾐ19 

1995年

（英文）

Saitoh, H., Takagaki, K., Majima, M., Nakamura, T., Matsuki, A., Kasai, M., Narita, H., and Endo, M.
Enzymic reconstruction of glycosaminoglycan oligosaccharide chain using the transglycosylation reaction of bovine testicular hyaluronidase.
J. Biol. Chem. (1995) 270, 3741ﾐ3747 

Nakamura, T., Takagaki, K., Shibata, S., Tanaka, K., Higuchi, T., and Endo, M.
Hyaluronic acid-defficient extracellular matrix induced by addition of 
4-methylumbelliferone to the medium of cultured human fibroblasts.
Biochem. Biophys. Res. Commun.(1995) 208, 470ﾐ475 

Yoshihara, S., Matsue, H., Sasaki, M., Shibata, S., Konn, M., Fukuzawa, A., and Endo, M.
Chemical structure of the carbohydrate moiety of fucose-rich glycopeptides from human pancreatic juice. 
Int. J. Pancreatol.(1995) 17, 181ﾐ187 

Shibata, S., Takagaki, K., Nakamura, T., Izumi, J., Kojima, K., Kato, I., and Endo, M. 
HNK-1-reactive novel oligosaccharide, sulfate-O-3GlcAβ1-4Xylβ1-(4-methylumbelliferone), synthesized by cultured human skin fibroblasts.
J. Biol. Chem. (1995) 270, 13794ﾐ13798 

Endo, M., Takagaki, K., Nakamura, T., and Majima, M.
Synthesis of recombinant glycosaminoglycan chains using the transglycosylation of endo-type glycosidases.
Glycoconjugate J. (1995) 12, 483 

Narita, H., Takeda, Y., Takagaki, K., Nakamura, T., Harata, S., and Endo, M.
Identification of glycosaminoglycans using high-performance liquid chromatography on a hydroxyapatite column.
Anal. Biochem. (1995) 232, 133ﾐ136

Takagaki, K., Nakamura, T., and Endo, M.
Reconstruction of glycosaminoglycans using the transglycosylation reaction of testicular hyaluronidase.
Connective Tissue (1995) 27, 207ﾐ211 

（和文）
高垣啓一、棟方秀和、中村敏也、遠藤正彦
高速液体クロマトグラフィーによる生体試料中のグリコサミノグリカン糖鎖分析
分析化学 (1995) 44 (10) , 789-791 

遠藤正彦、高垣啓一、中村敏也
 プロテオグリカン研究の新展開−エンド型グリコシダーゼによる糖鎖の組み換え
 生化学 (1995) 67 (11) , 1267-1282