研究業績
 
 

  2002年    2001年    2000年    1999年   1998年  
 

2002年 

(英文)

Iwafune M., Kakizaki, I., Yukawa, M., Kudo, D., Ota, S., Endo, M., and Takagaki, K.
Reconstruction of glycosaminoglycan chains in decorin.
Biochem. Biophys. Res., Commun. (2002) 297, 1167-1170

Kakizaki, I., Takagaki, K., Endo, Y., Kudo, D., Ikeya, H., Miyoshi, T., Baggenstoss, B. A., Tlapak-Simmons, V. L., Kumari, K., Nakane, A., Weigel, P. H., and Endo, M.
Inhibition of Hyaluronan Synthesis in Streptococcus equi FM100 by 4-Methylumbelliferone.
Eur. J. Biochem. (2002) 269, 5066-5075

Takagaki, K., Ishido K., Kakizaki, I., Iwafune, M., and Endo, M.
Carriers for enzymatic attachment of glycosaminoglycan chains to peptide
Biochem. Biophys. Res., Commun., (2002) 293, 220-4.

Takagaki K., Iwafune M., Kakizaki I., Ishido K., Kato Y., and Endo M.
The cleavage of the xylosyl serine linkage between a core peptide and a glycosaminoglycan chain by cellulases. 
J. Biol. Chem.,(2002) 277, 18397-403.

Ishido,K., Takagaki, K., Iwafune, M., Yoshihara, S., Sasaki, M., and Endo, M.
Enzymatic attachment of glycosaminoglycan chain to peptide using the sugar chain transfer reaction with endo-beta-xylosidase.
J. Biol. Chem., (2002) 277, 11889-95.

Takagaki, K., Munakata, H., Kakizaki, I., Iwafne, M., Itabashi, T., and Endo, M.
Domain structure of chondroitin sulfate E octasaccharides binding to type V collagen.
J Biol Chem.(2002) 277, 8882-9.

Daidouji K., Takagaki K., Yoshihara S., Matsuya H., Sasaki M., and Endo M. 
Neoplastic changes in saccharide sequence of dermatan sulfate chains derived from human colon cancer. 
Dig Dis Sci. (2002) 47, 331-337Top

2001年

 
(英文)
Yukawa, M., Takagaki, K., Itabashi, T., Ueyama, K. , Harata, S., and Endo, M.
Structural varieties of small proteoglycan in human spinal ligament. 
Connective Tissue Research (2001) 42 (3), 209-22

Majima, M., Takagaki, K., Sudo, S., Yoshihara, S., Kudo, Y., and Yamagishi, S.: 
Effect of proteoglycan on experimental colitis 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001)  221-224

Takagaki, K., Kakizaki, I., Iwafune, M., Ishido, K. and Endo, M.: 
Enzymatic reconstruction of glycosaminoglycan oligosaccharides 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001) 239-244

Endo, Y., Funahashi, M., Kakizaki, I., Takagaki, K., Endo, M., and Yokoyama, M.: 
Hyaluronan knockdown extracellular matrix of cultured human skin fibroblasts by use of 4-methylumbelliferone 
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands,  (2001) 265-268

Kakizaki, I., Takagaki, K., Endo, Y., Ikeya, H., Miyoshi, T., Nakane, A., Weigel, P. H. and Endo, M.
Effect of 4-methylumbelliferone on hyaluronan synthesis of Streptococcus equi FM100
In New Developments in Glycomedicine, edited by Endo, M. , Harata, S., Saito, Y., Munakata, A., Sasaki, M., and Tsuchida, S., Elsevier Science B. V., Amsterdam, the Netherlands, (2001) 269-272

Kukidome, J., Kakizaki, I., Takagaki, K., Matsuki, A., Munakata, A., and Endo, M. 
The mechanism of cell death in human cultured colon adenocarcinoma cell line COLO 201 induced by b-D- N -acetylglucosaminyl-p-nitrophenol
Tohoku J. Ex.p Med. (2001) 194, 23-34

Matsuya, H., Takagaki, K., Yoshihara, S., Ishido, K., Sasaki, M., and Endo, M.
Changes in glycosaminoglycan, galactosyltransferase-I, and sialyltransferase during rat liver regeneration.
Tohoku J. Exp. Med. (2001) 193, 187-195

Higuchi, T., Tamura, S., Tanaka, K., Takagaki, K., Saito, Y., and Endo, M.
Effects of ATP on regulation of galactosyl-transferase-I activity responsible for synthesis of the linkage region between the core protein and glycosaminoglycan chains of proteoglycans.
Biochem. Cell Biol. (2001) 79, 159-164

Kukidome, J., Kakizaki, I., Takagaki, K., Matsuki, A., Munakata, A., Endo, M.
Studies on sugar chain elongation in cultured human colon adenocarcinoma cells using 4-methylumbelliferyl glycoside derivatives and p-nitrophenyl glycoside derivatives as artificial primers.
Hirosaki Med. J. (2001) 52, 59-65

 (和文)
エンド-b -キシロシダーゼを用いたグリコサミノグリカン糖鎖の再構築.遠藤正彦, 高垣啓一, 柿崎育子, 石戸圭之輔
季刊科学総説「糖鎖分子の設計と生理機能」,日本化学会編, 学会出版センター48, pp14−32 (2001)

2000年

 
(英文)
Takagaki, K., Munakata, H., Kakizaki, I., Majima, M., Endo, M.
Enzymatic reconstruction of dermatan sulfate.
Biochem. Biophys. Res. Commun. (2000) 270 (2), 588-593

Takagaki, K., Munakata, H., Majima, M., Kakizaki, I., Endo, M.
Chimeric glycosaminoglycan oligosaccharides synthesized by enzymatic reconstruction and their use in substrate specificity determination of Streptococcus hyaluronidase.
J. Biochem. (Tokyo) (2000) 127 (4), 695-702

Matsuki, A., Takagaki, K., Kukidome, J., Endo, M., and Munakata, A.
Analysis of p-nitrophenyl N-Acetyl-a -D-galactosaminide-induced oligosaccharides produced by the cultured human colon adenocarcinoma cell, DLD-1.
Hirosaki Med. J. (2000) 52, 1-9 

Takagaki, K., and Ishido, K.
Synthesis of chondroitin sulfate oligosaccharides using enzymatic reconstruction.
Trends Glycosci. Glyc. (2000) 12 (67), 295-306 

Endo, Y., Takagaki, K., Takahashi, G., Kakizaki, I., Funahashi, M., Yokoyama, M., and Endo, M.
Formation of hyaluronic acid-knock-down extracellular matrix using 4-methylumbelliferone.
In Progress in Transplantation , edited by Munakata, A. Elsevier Science B. V., Amsterdam, the Netherlands, (2000) 1ミ7

(和文)
培養細胞によりβ-D-キシロシドをプライマーとして合成されたオリゴ糖
高垣啓一、遠藤正彦
生化学(2000)72(10)1263 -1266

1999年

 
(英文) Takagaki, K., Munakata, H., Majima, M., and Endo, M.
Enzymatic reconstruction of a hybrid glycosaminoglycan containing 6-sulfated, 4-sulfated, and unsulfated N -acetylgalactosamine.
Biochem. Biophys. Res. Commun. (1999) 258, 741-744 

Munakata, H., Takagaki, K., Majima, M, and Endo, M.
Interaction between collagens and glycosaminoglycans investigated using a surface plasmon resonance biosensor.
Glycobiology (1999) 9 (10), 1023-1027 

Takagaki, K., Kakizaki, I., and Endo, M
Development of an enzymatic synthesis method for chimeric glycosaminoglycans.
Hirosaki Med. J. (1999) 51 (Suppl.), S49-S53

(和文)
HPAEC-PAD法によるヒアルロン酸オリゴ糖の分離と定量
須藤 晋一郎, 高垣 啓一, 棟方 秀和, 中村 渉, 松谷 英樹, 遠藤 正彦
J. Appl. Glycosci. (応用糖質科学) (1999) 46 (3), 299-302

1998年

 
(英文)
Takagaki, K., Muna.kata, H., Nakamura, W., Matsuya, H., Majima, M., and Endo, M.
Ion-spray mass spectrometry for identification of the nonreducing terminal sugar of glycosaminoglycan.
Glycobiology (1998) 8, 719-724

Takagaki, K., Tazawa, T., Munakata, H., Nakamura, T., and Endo, M.
Characterization of β -D-xyloside-initiated glycosaminoglycan synthesized by human skin fibroblasts in the presence of tunicamycin.
Glycoconjugate J. (1998), 15, 483-489

Tazawa, T., Takagaki, K., Matsuya, H., Nakamura, T., Sasaki, M., and Endo, M.
A novel 4-methylumbelliferyl- β-D-xyloside derivative, sulfate-O-3-xylosyl- β1-(4-methylumbelliferone), isolated from culture medium of human skin fibroblasts, and its role in 4-methylumbelliferone-initiated glycosaminoglycan biosynthesis.
Glycobiology (1998) 8, 879-884

Ono, A., Harata, S., Takagaki, K., and Endo, M.
Proteoglycans in the nucleus pulposus of canine intervertebral disc after chondroitinase ABC treatment.
J. Spin. Disord. (1998) 11, 253-260