研究業績（2000年以降）
A. 英文原著
63) Mori F, Nishie M, Piao Y-S, Kito K, Kamitani T, Takahashi H, Wakabayashi K. Accumulation of NEDD8 in neuronal and glial inclusions of neurodegenerative disorders. Neuropathol Appl Neurobiol 31: 53-61, 2005.
62) Yoshida H, Imaizumi T, Tanji K, Sakaki H, Metoki N, Hatakeyama M, Yamashita K, Ishikawa A, Tamai K, Sato Y, Kimura H, Satoh K. Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia. Mol Brain Res 133: 95-101, 2005.
61) Ikejima S, Sasaki S, Sashinami H, Mori F, Ogawa Y, Nakamura T, Abe Y, Wakabayashi K, Suda T, Nakane A. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice. Diabetes 54: 182-189, 2005.
60) Irie Y, Mori F, Keung W-M, Mizushima Y, Wakabayashi K. Expression of neuronal growth inhibitory factor (metallothionein-III) in the salivary gland. Physiol Res 53: 719-723, 2004.
59) Nakatsu F, Okada M, Mori F, Kumazawa N, Iwasa H, Zhu G, Kasagi Y, Kamiya H, Harada A, Nishimura K, Takeuchi A, Miyazaki T, Watanabe M, Yuasa S, Manabe T, Wakabayashi K, Kaneko S, Saito T, Ohno H. Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. J Cell Biol 167: 293-302, 2004.
58) Mori F, Nishie M, Tanno K, Sannohe S, Kuroda N, Wakabayashi K. Hydranencephaly with extensive periventricular necrosis and numerous ectopic glioneuronal nests. Neuropathology 24: 315-319, 2004.
57) Tomiyama M, Mori F, Kimura T, Ichinohe N, Wakabayashi K, Matsunaga M, Baba M. Hypertrophy of medial globus pallidus and substantia nigra reticulata in 6-hydroxydopamine-lesioned rats treated with L-DOPA: Implication for L-DOPA-induced dyskinesia in Parkinson's disease. Neuropathology 24: 290-295, 2004.
56) Nishie M, Mori F, Yoshimoto M, Takahashi H, Wakabayashi K. A quantitative investigation of neuronal cytoplasmic and intranuclear inclusions in the pontine and inferior olivary nuclei in multiple system atrophy. Neuropathol Appl Neurobiol 30: 546-554, 2004.
55) Nishie M, Mori F, Ogawa M, Sannohe S, Tanno K, Kurahashi K, Kuroda N, Wakabayashi K.
Multinucleated astrocytes in old demyelinated plaques in a patient with multiple sclerosis. Neuropathology 24: 248-253, 2004.
54) Imaizumi T, Hatakeyama M, Yamashita K, Yoshida H, Ishikawa A, Taima K, Satoh K, Mori F, Wakabayashi K. Interferon-gamma induces retinoic acid-inducible gene-I in endothelial cells. Endothelium 11: 169-173, 2004.
53) Ogawa M, Nishie M, Kurahashi K, Kaimori M, Wakabayashi K. Anti-Hu-associated paraneoplastic sensory neuronopathy with upper motor neurone involvement. J Neurol Neurosurg Psychiatry 75: 1051-1053, 2004.
52) Nishie M, Mori F, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K. Accumulation of phosphorylated alpha-synuclein in the brain and peripheral ganglia of patients with multiple system atrophy. Acta Neuropathol 107: 292-298, 2004.
51) Wakabayashi K, Takahashi H. Pathological heterogeneity in progressive supranuclear palsy and corticobasal degeneration. Neuropathology 24: 79-86, 2004.
50) Mori F, Nishie M, Yoshimoto M, Takahashi H, Wakabayashi K. Reciprocal accumulation of beta-synuclein in alpha-synuclein lesions in multiple system atrophy. Neuroreport 14: 1783-1786, 2003.
49) Imaizumi T, Kumagai M, Hatakeyama M, Tamo W, Yamashita K, Tanji K, Yoshida H, Satoh K. 15-Deoxy-D12,14-prostaglandin J2 inhibits the expression of granulocyte-macrophage colony-stimulating factor in endothelial cells stimulated with lipopolysaccharide. Prostaglandins Other Lipid Mediat 71: 293-299, 2003.
48) Mori F, Piao Y-S, Hayashi S, Fujiwara H, Hasegawa M, Yoshimoto M, Iwatsubo T, Takahashi H, Wakabayashi K. Alpha-synuclein accumulates in Purkinje cells in Lewy body disease but not in multiple system atrophy. J Neuropathol Exp Neurol 62: 812-819, 2003.
47) Tanji K, Toki T, Tamo W, Imaizumi T, Matsumiya T, Mori F, Takahashi H, Satoh K, Wakabayashi K. Glycogen synthase kinase-3beta phosphorylates synphilin-1 in vitro. Neuropathology 23: 205-208, 2003.
46) Tanji K, Irie Y, Uchida Y, Mori F, Satoh K, Mizushima Y, Wakabayashi K. Expression of metallothionein-III induced by hypoxia attenuates hypoxia-induced cell death in vitro. Brain Res 976: 125-129, 2003.
45) Tanji K, Mori F, Imaizumi T, Yoshida H, Satoh K, Wakabayashi K. Interleukin-1 induces tau phosphorylation and morphological changes in cultured human astrocytes. Neuroreport 14: 413-417, 2003.
44) Piao Y-S, Mori F, Hayashi S, Tanji K, Yoshimoto M, Wakabayashi K, Takahashi H. Alpha-Synuclein pathology affecting Bergmann glia of the cerebellum in patients with alpha-synucleinopathies. Acta Neuropathol 105: 403-409, 2003.
43) Piao Y-S, Wakabayashi K, Kakita A, Yamada M, Hayashi S, Morita T, Ikuta F, Oyanagi K, Takahashi H. Neuropathology with clinical correlations of sporadic amyotrophic lateral sclerosis: 102 autopsy cases examined between 1962 and 2000. Brain Pathol 12: 10-22, 2003.
42) Wakabayashi K, Mori F, Oyama Y, Kurihara A, Kamada M, Yoshimoto M, Takahashi H. Lewy bodies in Betz cells of the motor cortex in a patient with Parkinson's disease. Acta Neuropathol 105: 189-192, 2003.
41) Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM-Y, Trojanowski JQ, Mann D, Iwatsubo T. Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. J Biol Chem 277: 49071-49076, 2002.
40) Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K, Jellinger K, Lantos PL, Lippa PL, Mirra SS, Tabaton M, Vonsattel JP, Wakabayashi K, Litvan I. Office of rare diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol 61: 935-946, 2002.
39) Orimo S, Ozawa E, Oka T, Miura H, Tsuchiya K, Mori F, Wakabayashi K, Nagao T, Yokochi M. Sympathetic cardiac denervation in Parkinson's disease and pure autonomic failure but not in multiple-system atrophy. J Neurol Neurosurg Psychiatry 73: 776-777, 2002.
38) Imaizumi T, Matsumiya T, Tamo W, Shibata T, Fujimoto K, Kumagai M, Yoshida H, Cui X-F, Tanji K, Hatakeyama M, Wakabayashi K, Satoh K.15-deoxy-delta 12-14 prostaglandin J2 inhibits CX3CL1/fractalkine expression in human endothelial cells. Immunol Cell Biol 80: 531-536, 2002.
37) Tanji K, Mori F, Imaizumi T, Yoshida H, Matsumiya T, Tamo W, Yoshimoto M, Odagiri H, Sasaki M, Takahashi H, Satoh K, Wakabayashi K. Upregulation of alpha-synuclein by lipopolysaccharide and interleukin-1 in human macrophages. Pathol Int 52: 572-577, 2002.
36) Mori F, Hayashi S, Yamagishi S, Yoshimoto M, Yagihashi S, Takahashi H, Wakabayashi K. Pick's disease: Alpha- and beta-synuclein-immunoreactive Pick bodies in the dentate gyrus. Acta Neuropathol 104: 455-461, 2002.
35) Sakamoto M, Kakita A, Wakabayashi K, Takahashi H, Nakano A, Akagi H. Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate-dose exposure throughout gestation and lactation periods. Brain Res 949: 51-59, 2002.
34) Mori F, Tanji K, Yoshida Y, Wakabayashi K. Thalamic retrograde degeneration in the congenitally hydrocephalic rat is attributable to apoptotic cell death. Neuropathology 22: 186-193, 2002.
33) Wakabayashi K, Shimura T, Mizutani N, Koide A, Yamagiwa O, Mori F, Nishiyama K, Tanaka R, Takahashi H. Primary intracranial solitary leptomeningeal glioma: a report of 3 cases. Clin Neuropathol 21: 206-213, 2002
32) Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, Nishi N, Fujimoto K, Tanji K, Shibata T, Tamo W, Matsumiya T, Yoshida H, Cui X-F, Takanashi S, Hanada K, Okumura K, Yagihashi S, Wakabayashi K, Nakamura T, Hirashima M, Satoh K. Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukocyte Biol 72: 486-491, 2002.
31) Mori F, Tanji K, Yoshimoto M, Takahashi H, Wakabayashi K. Demonstration of alpha-synuclein immunoreactivity in neuronal and glial cytoplasm in normal human brain tissue using proteinase K and formic acid pretreatment. Exp Neurol 176: 98-104, 2002.
30) Yoshida H, Imaizumi T, Tanji K, Matsumiya T, Sakaki H, Kimura D, Cui X, Kumagai M, Tamo W, Shibata T, Hatakeyama M, Sato Y, Satoh K. Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. Brain Res 944: 65-72, 2002.
29) Tamo W, Imaizumi T, Tanji K, Yoshida H, Mori F, Yoshimoto M, Takahashi H, Fukuda I, Wakabayashi K, Satoh K. Expression of alpha-synuclein, the precursor of non-Abeta component of Alzheimer's disease amyloid, in human cerebral blood vessels. Neurosci Lett 326: 5-8, 2002.
28) Mori F, Tanji K, Yoshimoto M, Takahashi H, Wakabayashi K. Immunohistochemical comparison of alpha- and beta-synuclein in adult rat central nervous system. Brain Res 941:118-126, 2002.
27) Kawasaki K, Wakabayashi K, Koizumi T, Tanaka R, Takahashi H. Spinal cord involvement of primary central nervous system lymphomas: histopathological examination of 14 autopsy cases. Neuropathology 22: 13-18, 2002.
26) Piao Y-S , Hayashi S, Wakabayashi K, Kakita A, Aida I, Yamada M, Takahashi H. Cerebellar cortical tau pathology in progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathol 103: 469-474, 2002.
25) Hayashi S, Toyoshima Y, Hasegawa M, Umeda Y, Wakabayashi K, Tokiguchi S, Iwatsubo T, Takahashi H. Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation. Ann Neurol 51: 525-530, 2002.
24) Imaizumi T, Aratani S, Nakajima T, Carlson M, Matsumiya T, Tanji K, Ookawa K, Yoshida H, Tsuchida S, McIntyre TM, Prescott SM, Zimmerman GA, Satoh K. Retinoic acid-inducible gene-I (RIG-I) is induced in endothelial cells by LPS and regulates expression of COX. Biochem Biophys Res Commun 292: 274-279, 2002.
23) Wakabayashi K, Engelender S, Tanaka Y, Yoshimoto M, Mori F, Tsuji S, Ross CA, Takahashi H. Immunocytochemical localization of synphilin-1, an alpha-synuclein-associated protein, in neurodegenerative disorders. Acta Neuropathol 103: 209-214, 2002.
22) Mori F, Inenaga C, Yoshimoto M, Umezu H, Tanaka R, Takahashi H, Wakabayashi K. Alpha-synuclein immunoreactivity in normal and neoplastic Schwann cells. Acta Neuropathol 103: 145-151, 2002.
21) Kahle PJ, Neumann M, Ozmen L, M殕ler V, Odoy S, Okamoto N, Jacobsen H, Iwatsubo T, Trojanowski JQ, Takahashi H, Wakabayashi K, Bogdanovic N, Riederer P, Kretzschmar HA, Haass C. Selective insolubility of alpha-synuclein in human Lewy body diseases is recapitulated in a transgenic mouse model. Am J Pathol 159: 2215-2225, 2001.
20) Takahashi H, Wakabayashi K. The cellular pathology of Parkinson's disease.Neuropathology 21: 315-322, 2001.
19) Yoshida H, Imaizumi T, Kumagai M, Kimura K, Satoh C, Hanada N, Fujimoto K, Nishi N, Tanji K, Matsumiya T, Mori F, Cui X-F, Tamo W, Shibata T, Takanashi S, Okumura K, Nakamura T, Wakabayashi K, Hirashima M, Sato Y, Satoh K. Interleukin-1beta stimulates galectin-9 expression in human astrocytes. Neuroreport 12: 3755-3758, 2001.
18) Orimo S, Ozawa E, Oka T, Nakade S, Tsuchiya K, Yoshimoto M, Wakabayashi K, Takahashi H. Different histopathology accounting for a decrease in myocardial MIBG uptake in PD and MSA. Neurology 57: 1140-1141, 2001.
17) Matsumiya T, Imaizumi T, Fujimoto K, Cui X, Shibata T, Tamo W, Kumagai M, Tanji K, Yoshida H, Kimura H, Satoh K. Soluble interleukin-6 receptor alpha inhibits the cytokine-induced fractalkine/CX3CL1 expression in human vascular endothelial cells in culture. Exp Cell Res 269: 35-41, 2001.
16) Tanji K, Mori F, Nakajo S, Imaizumi T, Yoshida H, Hirabayashi T, Yoshimoto M, Satoh K, Takahashi H, Wakabayashi K. Expression of beta-synuclein in normal human astrocytes. Neuroreport 12: 2845-2848, 2001.
15) Yu S, Iwatsuki H, Ichinohe N, Mori F, Shoumura. 'In vivo perfusion-Turnbull's reaction' for Fe(II) histochemistry in non-anoxic/non-ischemic and anoxic/ischemic brains. Neurosci Lett 308: 79-82, 2001.
14) Tanji K, Imaizumi T, Yoshida H, Mori F, Yoshimoto M, Satoh K, Wakabayashi K. Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1beta. Neuroreport 12: 1909-1912, 2001.
13) Yoshida H, Imaizumi T, Fujimoto K, Matuo N, Kimura K, Cui X-F, Matsumiya T, Tanji K, Shibata T, Tamo W, Kumagai M, Satoh K. Synergistic stimulation, by tumor necrosis factor-alpha and interferon-gamma, of fractalkine expression in human astrocytes. Neurosci Lett 303: 132-136, 2001.
12) Wakabayashi K, Piao YS, Hayashi S, Kakita A, Yamada M, Takahashi H. Ubiquitinated neuronal inclusions in the neostriatum in patients with amyotrophic lateral sclerosis with and without dementia−A study of 60 patients 31 to 87 years of age. Clin Neuropathol 20: 47-52, 2001.
11) Tanji K, Imaizumi T, Matsumiya T, Itaya H, Fujimoto K, Cui X, Toki T, Ito E, Yoshida H, Wakabayashi K, Satoh K. Desferrioxamine, an iron chelator, upregulates cyclooxygenase-2 expression and prostaglandin production in a human macrophage cell line. Biochim Biophys Acta 1530: 227-235, 2001.
10) Piao YS, Hayashi S, Hasegawa M, Wakabayashi K, Yamada M, Yoshimoto M, Ishikawa A, Iwatsubo T, Takahashi H. Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration. Acta Neuropathol 101: 285-293, 2001.
9) Wakabayashi K, Kobayashi H, Kawasaki S, Kondo H, Takahashi H. Autosomal recessive spastic paraplegia with hypoplastic corpus callosum, multisystem degeneration and ubiquitinated eosinophilic granules. Acta Neuropathol 101: 69-73, 2001.
8) Cui X, Imaizumi T, Yoshida H, Tanji K, Matsumiya T, Satoh K. Lipopolysaccharide induces the expresssion of cellular inhibitor of apoptosis protein-2 in human macrophages. Biochim Biophys Acta 1524: 178-182, 2000.
7) Mori F, Tanji K, Wakabayashi K. Convulsive effects of thiophene, a heterocyclic hydrocarbon: Behavioral, electrographic and c-Fos immunocytochemical studies. Neuropathology 20: 304-308, 2000.
6) Mori F, Tanji K, Wakabayashi K. Thiophene, a sulfur-containing heterocyclic hydrocarbon, causes widespread neuronal degeneration in rats. Neuropathology 20: 283-288, 2000.
5) Mori F, Tanji K, Wakabayashi K. Widespread calcium deposits, as detected using the alizarin red S technique, in the nervous system of rats treated with methylmercury. Neuropathology 20: 210-215, 2000.
4) Kakita A, Wakabayashi K, Su M, Yoneoka Y, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmercury intoxication: consequence of the inherent brain lesions and cognitive dysfunction in maturity. Brain Res 877: 322-330, 2000.
3) Ichinohe N, Mori F, Shoumura K. A di-synaptic projection from the lateral cerebellar nucleus to the laterodorsal part of the striatum via the central lateral nucleus of the thalamus in the rat. Brain Res 880: 191-197, 2000.
2) Mori F, Fukaya M, Abe H, Wakabayashi K, Watanabe M. Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain. Neurosci Lett 285: 57-60, 2000.
1) Tanji K, Mori F. Hemorrhages of dorsal root ganglia and spinal cord in congenitally hydrocephalic HTX rat. Pathol Res Pract 196: 185-191, 2000.
B. 和文原著
1) 森 文秋、丹治邦和、吉田泰二、若林孝一. 先天性水頭症ラット(HTX)における脊髄神経節出血と痛覚過敏. 脳神経 53: 55-59, 2001.
C. 総説・著書
16) Tomiyama M, Mori F, Kimura T, Wakabayashi K, Matsunaga M. Hypertrophy of the medial globus pallidus in 6-hydroxydopamine-lesioned rats treated with levodopa. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 205-210, 2003.
15) Tamo W, Imaizumi T, Tanji K, Yoshida H, Mori F, Fukuda I, Wakabayashi K, Satoh K. Expression of alpha-synuclein in vascular endothelial and smooth muscle cells. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 173-180, 2003.
14) Mori F, Tanji K, Yoshimoto M, Takahashi H, Wakabayashi K. Widespread expression of alpha-synuclein in neuronal cytoplasm and glial cells in the central and peripheral nervous systems in human. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 165-172, 2003.
13) Tanji K, Mori F, Imaizumi T, Yoshida H, Yoshimoto M, Takahashi H, Satoh K, Wakabayashi K. Expression of alpha- and beta-synucleins in cultured astrocytes and the effects of inflammatory cytokines. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 157-164, 2003.
12) Wakabayashi K, Takahashi H. Alpha-Synuclein, synphilin-1 and inclusion body formation in alpha-synucleinopathies. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 149-156, 2003.
11) Yoshida H, Imaizumi T, Tanji K, Sato Y, Satoh K. Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes under hypoxia. In: Advances in Brain Research. Cerebrovascular Disorders and Neurodegeneration (eds. Satoh K, Suzuki S, Matsunaga M). Elsevier Science B.V., pp. 81-86, 2003.
10) 若林孝一. 脳神経外科医に必要な神経病理の基礎（８）. 変性疾患（２）系統変性疾患. 脳神経外科 31: 216-222, 2003.
9) 若林孝一、丹治邦和、森 文秋、高橋 均. Alphaシヌクレイノパチー脳におけるグリア細胞の病態. 神経進歩 46: 584-591, 2002.
8) 小澤鉄太郎、若林孝一、小柳清光. 多系統萎縮症の病態をめぐる研究の進歩−Alpha-synucleinと視交叉上核を中心に−. 脳神経 54: 111-117, 2002.
7) Kakita A, Wakabayashi K, Su M, Sakamoto M, Ikuta F, Takahashi H. Intrauterine methylmercury intoxication: pattern of neuronal degeneration in the fetal brain and effects on higher brain function at maturity. In: Understanding of Minamata disease. Methylmercury poisoning in Minamata and Niigata, Japan (eds. Takizawa Y, Osame M). Japan Public Health Association. pp. 85-93, 2001.
6) 若林孝一、朴 月善、高橋 均. Tauopathyの病理−孤発性frontotemporal dementiaをめぐる問題点−. 神経内科 55: 123-130, 2001.
5) 若林孝一、高橋 均. 多系統萎縮症における細胞死のメカニズム−オリゴデンドログリア-ミエリン連関の細胞病理−. 最新医学 56: 1600-1605, 2001.
4) 若林孝一、朴 月善、高橋 均. 多系統萎縮症(MSA)−Glio-neuronal synucleinopathy−. 病理と臨床 19: 733-737, 2001.
3) 若林孝一. 脳の老化と痴呆. 弘前市医師会報 275: 62-65, 2001.
2) 若林孝一、高橋 均. Parkinson病の病理−alpha-synuclein、synphilin-1とLewy小体の形成機構−. 日本臨床 58: 2022-2027, 2000.
1) 若林孝一、吉本 真、高橋 均. Conformational diseaseの病理. 神経内科 52: 399-406, 2000.