Hirosaki University Graduate School of Medicine
5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan
Tel: +81(Japan)-172-39-5008
Fax: +81(Japan)-172-39-5009
YAMADA Research Unit
Contact : Associate Professor Katsuya Yamada, PhD.
E-mail: kyamada@hirosaki-u.ac.jp
2017.4.6
Home Page Renewal
Now Accepting New Postdocs, Graduate Students, Technical Staff Members !
Neurons and Vessels in Cerebral Cortex Cortical Vessel Imaging
Real-time confocal microscope High-frequency firing
of typical SNr neuron
Research Interest
Relationships between neuronal activity and brain metabolism focusing on
midbrain and cortex
Publication
Nagatomo, K., Suga S. Saitoh, M., Kogawa, M., Kobayashi, K., Yamamoto, Y., and Yamada, K. Dopamine D1 receptor immunoreactivity on fine processes of GFAP-positive astrocytes in the substantia nigra pars reticulata of adult mouse. Front. Neuroanat. 11: (2017). Doi: 10.3389/fnana.2017.00003.
Shibasaki, K., Hosoi, N., Kaneko, R., Tominaga, M., and Yamada, K. Glycine release from astrocytes via functional reversal of GlyT1. J. Neurochem. 140: 395-403 (2017). doi:10.1111/jnc.13741.
Yamada, K. “Vascular potassium channels in NVC” pp 63-73, In, New Horizons in Neurovascular Coupling, A Bridge Between Brain Circulation and Neuronal Plasticity. (Progress in Brain Research 225) 279 pages, Ed. by. Masamoto, K., Hirase, H., Yamada, K. Elsevier, Amsterdam (2016).
Yamada, K., Takahashi, S., Karube, F., Fujiyama, F., Kobayashi, K., Nishi, A., Momiyama, T. Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. J. Physiol. Sci. (2016). doi: 10.1007/s12576-016-0445-4.
Otsuka, Y., Sasaki, A., Teshima, T., Yamada, K., Yamamoto, T. Syntheses of D-Glucose Derivatives Emitting Blue Fluorescence through Pd-Catalyzed C-N Coupling. Org. Lett. 18: 1338-1341 (2016).
Yokoyama, H., Sasaki, A., Yoshizawa, T., Kijima, H., Hakamada, K., Yamada, K. Imaging hamster model of bile duct cancer in vivo using fluorescent L-glucose derivatives. Human Cell 29: 111-121 (2016).
Sasaki, A., Nagatomo, K., Ono, K., Yamamoto, T., Otsuka, Y., Teshima, T., Yamada, K. Uptake of a fluorescent L-glucose derivative 2-NBDLG into three-dimensionally accumulating insulinoma cells in a phloretin-sensitive manner. Human Cell 29: 37-45 (2016).
Sasaki, A., Nagatomo, K., Ono, K., Yamamoto, T., Otsuka, Y., Teshima, T., Yamada, K. Erratum to: Human Cell doi: 10.1007/s13577-016-0135-9. Pablished online: 17 February 2016.
Kurogi, M., Kawai, Y., Nagatomo, K., Tateyama, M., Kubo, Y., Saitoh, O. Auto-oxidation products of epigallocatechin gallate activate TRPA1 and TRPV1 in sensory neurons. Chem. Senses 40: 27-46 (2015).
Yamamoto, Y., Miyamoto, M., Tatsuda, D., Kubo, M., Nakagama, H., Nakamura, Y., Satoh, H., Matsuda, K., Watanabe, T., Ohta, T. A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability. Cancer Res. 74: 3707-3715 (2014).
Miyazaki, H., Oyama, F., Inoue, R., Aosaki, T., Abe, T., Kiyonari, H., Kino, Y., Kurosawa, M., Shimizu, J., Ogiwara, I., Yamakawa, K., Koshimizu, Y., Fujiyama, F., Kaneko, T., Shimizu, H., Nagatomo, K., Yamada, K., Shimogori, T., Hattori, N., Miura, M., Nukina, N. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum. Nat. Commun. 5: 5525 (2014). doi: 10.1038/ncomms6525.
Yamamoto, T., Tanaka, S., Suga, S., Watanabe, S., Nagatomo, K., Sasaki, A., Nishiuchi, Y., Teshima, T. and Yamada, K. Syntheses of 2-NBDG analogues for monitoring stereoselective uptake of D-glucose. Bioorg. Med. Chem. Lett. 21: 4088-4096 (2011).
Nagatomo, K., Ishii, H., Yamamoto, T., Nakajo, K. and Kubo, Y. The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression. Biophys. J. 99: 3609-3618 (2010).
Kurogi, M., Nagatomo, K., Kubo, Y. and Saitoh, O. Effects of spinophilin on the function of RGS8 regulating signals from M2 and M3-mAChRs. Neuroreport 20: 1134-1139 (2009).
Yamamoto, T., Nishiuchi, Y., Teshima, T., Matsuoka, H., and Yamada, K. Synthesis of 2-NBDLG, a fluorescent derivative of L-glucosamine; the antipode of D-glucose tracer 2-NBDG. Tetrahedron Lett. 49: 6876-6878 (2008).
Sakai, H., Tanaka, Y., Tanaka M., Ban, N., Yamada, K., Matsumura, Y., Sasaki, M., Kita, T., Inagaki, N. ABCA2 deficiency results in abnormal sphingolipid metabolism in mouse brain. J. Biol. Chem. 282: 19692-19699 (2007).
Yamada, K., Saito, M., Matsuoka, H., Inagaki, N. A real-time imaging method of glucose uptake in single, living mammalian cells. Nature Protocols 2: 753-762 (2007).
Miyake, A., Yamada, K., Kosaka, T., Miki, T., Seino, S., Inagaki, N. Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice. Eur J Neurosci. 25: 2349-236 (2007).
Saito, T., Yamada, K., Wang, Y., Tanaka, Y., Ohtomo, K., Ishikawa, K., Inagaki, N. Expression of ABCA2 protein in both non-myelin-forming and myelin-forming Schwann cells in the rodent peripheral nerve. Neurosci. Lett. 414: 35-40 (2007).
Sato, S., Yamada, K., and Inagaki, N. Systems for simultaneously monitoring heart and breathing rate in mice using a piezoelectric transducer. Med. Bioeng. Comput. 44: 353-362 (2006).
Yamada, K., and Inagaki, N. Neuroprotection by KATP channels. J. Mol. Cell. Cardiol. 38: 945-949 (2005).
Wang, Y., Yamada, K., Tanaka, Y., Ishikawa, K., and Inagaki, N. Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. J. Neurol. Sci. 232: 59-63 (2005).
Yuan, H., Yamada, K., Inagaki, N. Multiminute oscillations in mouse substantia nigra pars reticulata neurons in vitro. Neurosci. Lett. 355: 136-140 (2004).
Tanaka, U., Yamada, K., Zhou C.-J., Ban, N., Shioda, S., and Inagaki, N. Temporal and spatial profiles of ABCA2-expressing oligodendrocytes in the developing rat brain. J. Comp. Neurol. 455: 353-367 (2003).
Yamada, K., and Inagaki, N. ATP-sensitive potassium channels in the Brain: a sensor of hypoxic conditions. News Physiol. Sci. 17: 127-130 (2002).
Ogura, T., Furukawa, T., Toyozaki, T., Yamada, K., Y.-U, Zheng, Katayama, Y., Nakaya, H., and Inagaki, N. ClC-3B, a novel ClC-3 splicing variant that interacts with EBP50 and facilitates expression of CFTR-regulated ORCC. FASEB J. 16: 863-865 (2002).
Yamada, K., and Inagaki, N. Metabolic control of the seizure gate: a role for neuronal K-ATP channels. Trends Pharmacol. Sci. 22: 601-602 (2001).
Yamada, K., Ji, J.-J., Yuan, H., Miki, T., Sato, S., Horimoto, N., Shimizu, T., Seino, S., and Inagaki, N. Protective role of ATP-sensitive potassium channels in hypoxia-induced generalized seizure. Science 292: 1543-1546 (2001).
Yamada, K., Yamamoto, N., and Toyama, K. Development of NMDA and non-NMDA receptor-mediated excitatory synaptic transmission in geniculocortical and corticocortical connections studied by organotypic coculture preparations. Eur. J. Neurosci. 12: 3854-3862 (2000).
Fujita, H., Matsuura, T., Yamada, K., Inagaki, N., and Kanno, I. A sealed cranial window system for simultaneous recording of blood flow, electrical and optical signals in the rat barrel cortex. J. Neurosci. Methods. 99: 71-78 (2000).
Yamada, K., Nakata, M., Horimoto, N., Saito, M., Matsuoka, H., and Inagaki, N. Measurement of glucose uptake and intracellular calcium concentration in single, living pancreatic β-cells. J. Biol. Chem. 275: 22278-22283 (2000).
Yamada, K., Yamamoto, N., and Toyama, K. Development of membrane properties of rat neocortical neurons studied in organotypic cocultures. Neurosci. Lett. 275: 65-68 (1999).
Matsuura, T., Fujita, H., Seki, C., Kashikura, K., Yamada, K., and Kanno I. CBF Change evoked by somatosensory activation measured by laser-Doppler flowmetry: Independent evaluation of RBC velocity and RBC concentration. Jpn. J. Physiol. 49: 289-296 (1999).
Malonek, D., Dirnagl, U., Lindauer, U., Yamada, K., Kanno, I., and Grinvald, A. Vascular imprints of neuronal acitvity: Relationships between the dynamics of cortical blood flow, oxygenation, and volume changes following sensory stimulation. >strong>Proc. Natl. Acad. Sci. USA 94: 14826-14831 (1997).
Yamamoto, N., Yamada, K., Kurotani, T., and Toyama, K. Laminar Specificity of Extrinsic Cortical Connections Studied in Coculture Preparations. Neuron 9: 217-228 (1992).
Toyama, K., Komatsu, Y., Yamamoto, N., Kurotani, T., and Yamada, K. In vitro approach to visual cortical development and plasticity. Neurosci. Res. 12: 57-71 (1991).
