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Achievement

2021

Paper

  • Dorion M-F, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H. The CD36 ligand-promoted autophagy protects retinal pigment epithelial cells from oxidative stress. Oxid Med Cell Longev 6691402, 2021.
  • Matsumoto M, Suganuma H, Ozato N, Shimizu S, Katashima M, Katsuragi Y, Mikami T, Itoh Ken, Nakaji S. Association between Serum Concentration of Carotenoid and Visceral Fat. Nutrients 13(3):912, 2021.
  • Nakamura K, Kojima R, Uchino E, Ono K, Yanagita M, Murashita K, Itoh K, Nakaji S, Okuno Y. Health improvement framework for actionable treatment planning using a surrogate Bayesian model. Nat Commun 12(1):3088, 2021.
  • Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S, Ichihara G. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology 456:152785, 2021.
  • Yamamoto H, Suzuki M, Matsuta R, Sasaki K, Kang MI, Kami K, Tatara Y, Itoh K, Nakaji S. Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study. Metabolites 11(5):314, 2021.
  • Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T. Characterization of mitochondrial calpain-5. Biochim Biophys Acta Mol Cell Res 1868(5):118989, 2021.

2020

Paper

  • Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K. Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Biomolecules. 2020 Feb 17;10(2)
  • Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.?PLoS Genet. 2020 Apr 23;16(4):e1008693.
  • Yokono Y, Hanada K, Narita M, Tatara Y, Kawamura Y, Miura N, Kitayama K, Nakata M, Nozaka M, Kato T, Kodo N, Tsushima M, Toyama Y, Itoh K, Tomita H. Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice. J Am Heart Assoc. e015616, 2020.
  • Yamazaki H., Itoh K.(2020) Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation. In: Deng H.(eds) Nrf2 and its Modulation in Inflammation. Progress in Inflammation Research, vol 85. Springer, Cham DOI:10.1007/978-3-030-44599-7_4
  • Maeda Y, Sasaki A, Kasai S, Goto S, Nishio S, Sawada K, Tokuda I, Itoh K, Usami S, Matsubara A. Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan. Human Genome Variation in press.
  • Matsumoto M, Waki N, Suganuma H, Takahashi I, Kurauchi S, Sawada K, Tokuda I, Misawa M, Ando M, Itoh K, Ihara K, Nakaji S. Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness. Nutrients. 2020 Jul 31;12(8):E2310.
  • Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K. Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging. PLoS One. 2020 Aug 11;15(8):e0236834.

2019

Paper

  • Sehsah R, Wu W, Ichihara S, Hashimoto N, Hasegawa Y, Zong C, Itoh K, Yamamoto M, Elsayed AA, El-Bestar, Kamel E, Ichihara G. Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles. Part Fibre Toxicol 16(1):47, 2019.
  • Kasai S, Yamazaki H, Tanji K, Mate Janos Engler, Matsumiya T, Itoh K. Role of ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control. J Clin Biochem Nutr 2019;64:1-12.
  • Suto A, Kudo D, Yoshida E, Nagase H, Suto S, Mimura J, Itoh K, Hakamada K. Increase of Tumor Infiltrating ??T-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone. Pancreas. 2019;48:292-298.
  • Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes. Int J Mol Sci 20, 2019.
  • Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K. Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.?Arch Pharm Res. 2020 Mar;43(3):286-296.

2018

Paper

  • Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. Sci Rep 2018;8:8037.
  • Nakamura T, Kawarabayashi T, Seino Y, Hirohata M, Nakahara N, Narita S, Itoh K, Nakaji S, Shoji M. Aging and APOE-e4 are determinative factors of plasma Ab42 levels. Annals Clin. Trans. Neurol. 2018;5:1184-1191.
  • Kasai S, Mimura J, Ozaki T, Itoh K. Emerging regulatory role of Nrf2 in iron, heme and hemoglobin metabolism in physiology and disease. Front.Vet Sci 2018;5:242.

2017

Paper

  • Kasai S, Richardson M. J. E., Torii S, Yasumoto K, Shima H, Igarashi K, Itoh K, Sogawa K, Murayama K. Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS J 2017;284:4115-4127.
  • K.Tatara Y, Suto S, Itoh K. Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin. Glycobiology.2017;27:1089-1098.
  • Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J 2017;31:4011-4022.

2016

Paper

  • Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. The role of NUB1 in ?-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016;470:635-642.
  • Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T. The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects in combination with quinone-containing compounds and anti-microtubule drugs. Oncotarget.2016;7:79217-79232.