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I thought not only cause an infection, bacteria and viruses, and deeply involved as well as indirect trigger autoimmune diseases and in disease of unknown etiology. Research from the perspective of mediators secreted by the immune cells of the host defense against infection cytokine responses, we are aiming at the prevention and treatment by modification of cytokine in vivo. I thought not only cause an infection, bacteria and viruses, and deeply involved as well as indirect trigger autoimmune diseases and in disease of unknown etiology. Research from the perspective of mediators secreted by the immune cells of the host defense against infection cytokine response, bacteriological course is aimed at the prevention and treatment by modification of cytokine in vivo. On the other hand, the immune system has an important role in the maintenance of homeostasis. To maintain that that not only the immune system, nervous system, endocrine system and the network is involved is known. I thought 'cytokine' in the cross-talk of this network plays a central role, imbalance of cytokine balance to cause various diseases. I thought 'cytokine' in the cross-talk of this network plays a central role, imbalance of cytokine balance to cause various diseases.
In intracellular parasitic bacteria, Listeria sepsis in humans cause meningoencephalitis due to opportunistic infections as well as M. tuberculosis. The host of the Th1 type immune response is directed against typical Listeria infection, have been widely used as a model for analysis of cell-mediated immunity dressed. In intracellular parasitic bacteria, Listeria sepsis in humans cause meningoencephalitis due to opportunistic infections as well as M. tuberculosis. The host of the Th1 type immune response is directed against typical Listeria infection, have been widely used as a model for analysis of cell-mediated immunity dressed.
Defense immune system is responsible. However, considering that from a global perspective homeostasis, the immune system has formed a network with the nervous system and endocrine system. In order to elucidate the mechanism of defense, it is necessary to know their crosstalk. We, in mice irreversibly blocking the sympathetic nervous system has been found to reveal that the resistance to Listeria infection is enhanced, under the control of the sympathetic nervous system infection with Listeria defense. I also found that (MIF) is contribute to the death of Listeria infection migration inhibitory factor is a cytokine that is produced by the pituitary gland. In addition, we are investigating the corticotropin-releasing hormone and involvement of the parasympathetic nervous system (CRH) currently.
Staphylococcus aureus bacteria are important as a major cause of hospital-acquired infections as MRSA. In addition, (SE), toxic shock syndrome toxin-1 (TSST-1) activity has a superantigen, various immunological modifications have been made to staphylococcal enterotoxin producing Staphylococcus aureus. We have shown that the protection against infection by Staphylococcus aureus infection is carried out under the delicate balance of the positive and negative effects of IFN-γ. We have shown that the protection against infection by Staphylococcus aureus infection is carried out under the delicate balance of the positive and negative effects of IFN-γ. We also investigate the relevance of superantigen activity and emetic activity of SEA. Furthermore, they also pointed out the relevance of infection with Staphylococcus aureus and atopic dermatitis, have studied the mutual relevance.
Due to the balance between host and pathogen, relapse caused by persistent infection of immunocompromised host. Using gene knockout mutants related stress and flagella of Salmonella typhimurium proteins, we have investigated from the point of view of the balance of pro-inflammatory cytokines and anti-inflammatory cytokine mechanisms that persistent infection. This study is a joint research project with Professor Tomoko Yamamoto Chemistry Graduate School of Pharmaceutical Sciences, Chiba Institute of Microbial drug.
Inflammatory bowel disease such as ulcerative colitis, Crohn's disease represents a refractory, the establishment of the elucidation of the pathogenesis and treatment of which are urgent. We, that using a mouse model of inflammatory bowel disease treated mice dextran sulfate, IL-10 knockout mice, and OX40L transgenic mice, it is important to mucosal damage is the collapse of the balance between TGF-β and IFN-γ revealed. From this point of view, I have done the pursuit of new treatment strategies for inflammatory bowel disease.
I considered compromised in patients with diabetes, but a variety of factors are involved, there is said to be the basis of the level of degradation or failure of the immune system. Using (db / db mice) mouse model of diabetes type Ⅰ and type Ⅱ diabetes model mice (mice treated with Streptozotocin) diabetes as a model, we have analyzed the mechanism of increased susceptibility to infection. Also, since it is of leptin receptor-deficient mice, db / db mice are also in parallel to investigate the involvement of leptin in defense bacterial infection.
Cause human allergies and allergic reactions for some allergens, but also makes it easier to react readily with respect to other allergens, its mechanism is not known. We are conducting research to produce a contact dermatitis model hapten egg white allergy and sumac, to analyze the interaction between allergic reaction, to clarify the mechanism of induction allergic march.