古川－研究業績（原著論文）
  

［ 原著論文 ］下線太字の数字は First Author and/or Corresponding Author

1.  Furukawa K-I, Ikebe M, Inoue A, Tonomura Y
The amount of nucleotide binding and the Pi-burst size of myosin adenosine-triphosphatase:
evidence for the nonidentical two-headed structure of myosin.
Journal of Biochemistry 1980; 88: 1629-1641

2.  Furukawa K-I, Inoue A, Tonomura Y
Extra burst of Pi liberation and formation of the myosin-phosphate-ADP complex at various concentrations
of Mg2+ ions.
Journal of Biochemistry 1981; 89: 1283-1292

3.  Furukawa K-I, Tonomura Y
The conventional and saturation transfer electron paramagnetic resonance of spin-labeled myosin
subfragment-1 in the presence of F-actin and nucleotides.
Journal of Biochemistry 1982; 92: 1219-1225

4.  Furukawa K-I, Arata T
Effect of tryptic digestion of myosin subfragment-1 on its binding to F-actin.
Journal of Biochemistry 1984; 95: 1343-1348

5.  Furukawa K-I, Nakamura H
Characterization of the (Ca2+-Mg2+)-ATPase purified by calmodulin-affinity chromatography from
bovine aortic smooth muscle.
Journal of Biochemistry 1984; 96: 1343-1350

6.  Furukawa K-I, Nakamura H
Cyclic GMP regulation of the plasma membrane (Ca2+-Mg2+)-ATPase in vascular smooth muscle.
Journal of Biochemistry 1987; 101: 287-290

7.  Tawada Y, Furukawa K-I, Shigekawa M
ATP-induced calcium transient in cultured rat aortic smooth muscle cells.
Journal of Biochemistry 1987; 102: 1499-1509

8. Furukawa K-I, Tawada Y, Shigekawa, M.
Regulation of the plasma membrane Ca2+ pump by cyclic nucleotides in cultured vascular smooth muscle cells.
Journal of Biological Chemistry 1988; 263: 8058-8065

9. Tawada, Y., Furukawa K-I, Shigekawa, M.
Cyclic AMP enhances inositol triphosphate-induced mobilization of intracellular Ca2+ in cultured aortic
smooth muscle cells.
Journal of Biochemistry 1988; 104: 795-800

10. Takata S. Hirata Y. Furukawa K-I, Tomita M Takagi Y Fujita T, Hidaka H
Concomitant increase in cytosolic free calcium and phosphorylation of myosin light chain by
vasoconstrictive hormones in cultured rat vascular smooth muscle cells
Endocrinologia Japonica 1988; 35: 577-584

11. Furukawa K-I, Tawada Y, Shigekawa M.
Protein kinase C activation stimulates plasma membrane Ca2+ pump in cultured vascular smooth muscle cells.
Journal of Biological Chemistry 1989; 264: 4844-4849

12. Furukawa K-I, Tawada-Iwata Y, Shigekawa M
Modulation of plasma membrane Ca2+ pump by membrane potential in cultured vascular smooth muscle cells.
Journal of Biochemistry 1989; 106: 1068-1073

13. Ogurusu T, Wakabayashi S, Furukawa K-I, Tawada-Iwata Y, Imagawa T, Shigekawa M
Protein kinase-dependent phosphorylation of cardiac sarcolemmal Ca2+-ATPase, as studied with a specific
monoclonal antibody.
Journal of Biochemistry 1990; 108: 222-229

14. Fukuda T, Ogurusu T, Furukawa K-I, Shigekawa M
Protein kinase C-dependent phosphorylation of sarcolemmal Ca2+-ATPase isolated from bovine aortic
smooth muscle.
Journal of Biochemistry 1990; 108: 629-634

15. Takasago T, Imagawa T, Furukawa K-I, Ogurusu T, Shigekawa M
Regulation of the cardiac ryanodine receptor by protein kinase-dependent phosphorylation.
Journal of Biochemistry 1991; 109: 163-170

16. Furukawa K-I, Ohshima N, Tawada-Iwata Y, Shigekawa M
Cyclic GMP stimulates Na+/Ca2+ exchange in vascular smooth muscle cells in primary culture.
Journal of Biological Chemistry 1991; 266: 12337-12341

17. Tawada-Iwata Y, Furukawa K-I, Ogurusu T, Shigekawa M
Altered agonist-induced Ca2+ mobilization in aortic smooth muscle cells from cardiomyopathic hamsters.
American Journal of Physiology 1992; 263: H68-H74

18. Taniguchi J, Furukawa K-I, Shigekawa M
Maxi K+ channel activity stimulated by cGMP dependent protein kinase in coronary smooth muscle.
Pfluger Archive - European Journal of Physiology 1993; 423: 167-172

19. Furukawa K-I, Sakai K, Watanabe K, Maruyama K, Murakami M, Yamaguchi K, Ohizumi Y
Goniodomin A induces modulation of actomyosin-ATPase activity mediated through conformational change of actin.
Journal of Biological Chemistry 1993; 268: 26026-26031

20. Ohkura, M, Furukawa K-I, Ohizumi, Y.
Calsequestrin is a major binding protein of myotoxin a, a powerful Ca2+ releaser in sarcoplasmic reticulum.
European Journal of Pharmacology 1994; 268: R1-R2

21. Seino A, Furukawa K-I, Miura T, Momose K, Ohizumi Y
3', 3", 5', 5"-Tetraiodophenolsulfonephthalein is a specific inhibitor of the sarcoplasmic reticulum Ca2+-ATPase.　
Journal of Biological Chemistry 1994; 269: 17550-17555

22. Furukawa K-I, Funayama K, Ohkura M, Oshima Y, Tu AT, Ohizumi Y
Ca2+ release induced by myotoxin a, a radio-labelable probe having novel Ca2+ release properties in
sarcoplasmic reticulum.
British Journal of Pharmacology 1994; 113: 233-239

23. Takahashi Y, Furukawa K-I, Ishibashi, S, Kozutsumi D, Ishiyama H, Kobayashi J, Ohizumi Y
Structure-activity relationship of bromoeudistomin D, a powerful Ca2+ releaser in skeletal muscle
sarcoplasmic reticulum.
European Journal of Pharmacology 1995; 288: 285-293

24. Takahashi Y, Furukawa K-I, Kozutsumi D, Ishibashi M, Kobayashi J, Ohizumi Y
4,6-Dibromo-3-hydroxycarbazole of analogue of caffeine-like Ca2+ releaser, a novel type of inhibitors
of Ca2+-induced Ca2+ in skeletal muscle sarcoplasmic reticulum.
British Journal of Pharmacology 1995; 114: 941-948

25. Ohkura M, Furukawa K-I, Oikawa K, Ohizumi, Y
The properties of specific binding site of 125I-radioiodinated myotoxin a, a novel Ca2+ releasing agent,
in skeletal muscle sarcoplasmic reticulum.
Journal of Pharmacology and Experimental Therapeutics 1995; 273: 934-939

26. Ohkura M, Ide T, Furukawa K-I, Kawasaki T, Kasai M, Ohizumi Y
Calsequestrin is essential for the C2+ release induced by myotoxin a in skeletal muscle sarcoplasmic reticulum.
Canadian Journal of Physiology and Pharmacology 1995; 73: 1181-1185

27. Sakamoto H, Furukawa K-I, Nakamura H, Ohizumi Y
Xestoquinone activates skeletal muscle actomyosin ATPase by the modification of myosin sulfhydryl
groups probably distinct from sulfhydryl groups SH1 and SH2.
Biochemistry 1995; 34: 12570-12575

28. Yoshikawa K, Furukawa K-I, Yamamoto M, Kobayashi M, Momose K, Ohizumi, Y.
9-[3H]Methyl-7-bromoeudistomin D, having caffeine-like properties, binds to specific sites in
guinea pig brain microsomes.
FEBS Letters 1995; 373: 250-254

29. Furukawa K-I, Ohizumi Y
Regulation of intracellular Ca2+ concentration of vascular smooth muscle cells.

　  Journal of Smooth Muscle Research 1995; 31: 21-23

30. Furukawa K-I, Komaba J, Sakai H, Ohizumi Y
The mechanism of acidic pH-induced contraction in aortae from SHR and WKY rats enhanced
by increasing blood pressure.
British Journal of Pharmacology 1996; 118: 485-492

31. Furukawa K-I, Shibusawa K, Chairungsrilerd N, Ohta T, Nozoe S, Ohizumi Y
The mode of inhibitory action of a-mangostin, a novel inhibitor, on the sarcoplasmic reticulum
Ca2+-pumping ATPase from rabbit skeletal muscle.
Japanese Journal of Pharmacology 1996; 71: 337-340

32. Chairungsrilerd N, Furukawa K-I, Ohta T, Nozoe S, Ohizumi Y
Histaminergic and serotonergic blocking substances from the medicinal plant Garcinia mangostana.
Planta Medica 1996; 62: 471-472

33. Chairungsrilerd N, Furukawa K-I, Ohta T, Nozoe S, Ohizumi Y
Pharmacological properties of a-mangostin, a novel histamine H1 receptor antagonist.

      European Journal of Pharmacology 1996; 314: 351-356

34. Furukawa K-I, Matsuzawa M, Tsurufuji S, Watanabe K, Ohizumi Y
The mechanism of rabbit platelet aggregation induced by 2,5-Di-(tert-butyl)-1,4-benzohydroquinone,
an inhibitor of endoplasmic reticulum Ca2+-ATPase.
Japanese Journal of Pharmacology 1997; 75: 295-298

35. Chairungsrilerd N, Furukawa K-I, Ohta T, Nozoe S, Ohizumi Y
g-Mangostin, a novel type of 5-hydroxytryptamine 2A receptor antagonist.
Naunyn-Schmiedeberg's Archives of Pharmacology 1998; 357: 25-31

36. Chairungsrilerd N, Furukawa K-I, Tadano T, Kisara K, Ohizumi Y
Effect of g-mangostin through the inhibition of 5-hydroxy-tryptamine2A receptors in
5-fluoro-a-methyltryptamine-induced head-twitch responses of mice.
British Journal of Pharmacology 1998; 123: 855-862

37. Ohkura M, Furukawa K-I, Fujimori H, Kuruma A, Kawano S, Hiraoka M, Kuniyasu A, Nakayama H, Ohizumi Y
Dual regulation of the skeletal muscle ryanodine receptor by triadin and calsequestrin.
Biochemistry 1998; 37: 12987-12993

38. Takeuchi K, Senba S, Furukawa K-I, Eto M, Morita F
Localization of 17-kDa myosin light chain isoforms in cultured aortic smooth muscle cells.

      Journal of Biochemistry 1999; 125: 334-342

39. Kuniyasu A, Kawano S, Hirayama Y, Ji Y-H, Hu K, Ohkura M, Furukawa K-I, Ohizumi Y, Hiraoka M, and Nakayama H
A new scorpion toxin (BmK-PL) stimulates Ca2+-release channel activity of the skeletal-muscle
ryanodine receptor by an indirect mechanism.
Biochemical Journal 1999; 339: 343-350

40. Seya K, Furukawa K-I, Motomura S
A fluorometric assay for cyclic guanosine 3', 5'-monophosphate incorporating Sep-Pak cartridge
and enzymatic cycling method.
Analytical Biochemistry 1999; 272: 243-249

41. Nakatani K, Murayama T, Satoh Y, Furukawa K-I, Omura S, Ohizumi Y
Modulation of actomyosin ATPase by thiotetromycin is mediated through conformational change of actin.
European Journal of Pharmacology 1999; 383: 381-386

42. Terui K, Higashiyama A, Horiba N, Furukawa K-I, Motomura S, Suda T
Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart.
ACTH Related Peptides 1999; 10: 61-65

43. Nakao M, Furukawa K-I, Satoh E, Ono K, Iijima T
Inhibition by antisense oligonucleotides of plasma membrane Ca2+ ATPase in vascular endothelial cells.
European Journal of Pharmacology 2000; 387: 273-277

44. Takaya Y, Kikuchi H, Terui Y, Komiya J, Furukawa K-I, Seya K, Motomura S, Ito A, and Oshima Y
Novel Acyl α-Pyronoids, Dictyopyrone A, B and C, from Dictyostelium Cellular Slime Molds.
Journal of Organic Chemistry 2000; 65: 985-989

45. Uwai K, Ohashi K, Takaya Y, Oshima Y, Furukawa K-I, Yamagata K, Omura T, Okuyama S
Virol A, a Toxic Polyacetylenic Alcohol of Cicuta virosa, inhibits the GABA-induced Cl-Current
in the Rat Hippocampal CA1 Neurons.
Brain Research 2001; 889: 174-180

46. Terui K, Higashiyama A, Horiba N, Furukawa K-I, Motomoura S, Suda T
Coronary vasodilation and positive inotropism by urocortin in the isolated rat heart.

      Journal of Endoclinology 2001; 169: 177-183

47. Fujiwara H, Matsunaga K, Saito M, Hagiya S, Furukawa K-I, Nakamura H, Ohizumi Y
Halenaquinone, a novel phosphatidyl inositol 3-kinase inhibitor from a marine sponge, induces
apoptosis in PC12 cell.
European Journal of Pharmacology 2001; 413: 37-45

48. Akaishi K, Furukawa K-I, Yamamoto Y, Ueyama K, Tanno M, Harata S
Analysis of genes regulated by CTGF/HCS24 in ligament cells from patients with ossification of
the posterior longitudinal ligament.
Hirosaki Medical Journal 2001; 52: 66-71

49. Moriya T, Furukawa K-I, Nakamura H, Ohizumi Y
The vaso-contractile action of zooxanthellatoxin-B from a marine dinoflagellate is mediated via
massive Ca2+ influx in the rabbit aorta.
Canadian Journal of Physiology and Pharmacology 2001; 79: 1030-1035

50. Yamamoto Y, Furukawa K-I, Ueyama, Nakanishi T, Takigawa M, Harata S
Possible Roles of CTGF/Hcs24 in the initiation and development of ossification of the posterior
longitudinal ligament.
Spine 2002; 27: 1852-1857

51. Sasamura S, Furukawa K-I, Shiratori M, Motomura S, Ohizumi Y
Antisense-inhibition of plasma Membrane Ca2+ pump induces apoptosis in vascular smooth muscle cells.
Japanese Journal of Pharmacology 2002; 90: 164-172

52. Rohra DK, Yamakuni T, Furukawa K-I, Ishii N, Shinkawa T, Isobe T, and Ohizumi Y
Stimulated tyrosine phosphorylation of phosphatidylinositol 3-kinase causes acidic pH-induced contraction
in spontaneously hypertensive rat aorta.
Journal of Pharmacology and Experimental Therapeutics 2002; 303: 1255-1264

53. Saito SY, Furukawa K-I, Ohizumi Y
Injury by acidosis in cardiovascular system.
Pharmacometrics 2002; 62: 91-96.

54. Ohishi H, Furukawa K-I, Iwasaki K, Ueyama K, Okada A, Motomura S, Harata S, Toh S
Role of prostaglandin I2 in the gene expression induced by mechanical stress in spinal ligament cells
derived from patients with ossification of the posterior longitudinal ligament.
Journal of Pharmacology and Experimental Therapeutics 2003; 305: 818-824

55. Seya K, Furukawa K-I, Taniguchi S, Takaya Y, Kodzuka G, Oshima Y, Niwa M, Motomura S
Endothelium-dependent vasodilatory effect of vitisin C, a novel plant oligostilbene from
Vitis Coignetiae (Vitaceae) in rabbit aorta.
Clinical Science 2003; 105: 73-79

56. Tanno M, Furukawa K-I, Ueyama K, Harata S, Motomura S
Uni-axial cyclic stretch induces osteogenic differentiation and syntheses of bone morphogenetic proteins
of spinal ligament cells derived from patients with ossification of the posterior longitudinal ligaments.
Bone 2003; 33: 475-484

57. Kageyama K, Furukawa K-I, Miki I, Terui K, Motomura S, Suda T
Vasodilative effects of urocortin II via protein kinase A and a mitogen-activated protein kinase in rat thoracic aorta.
Journal of Cardiovascular Pharmacology 2003; 42: 561-565

58. Tanaka T, Ikari K, Furushima K, Okada A, Tanaka H, Furukawa K-I, Yoshida K, Ikeda T, Ikegawa S,
Hunt S, Takeda J, Toh S, Harata S, Nakajima T, and Inoue I
Genomewide linkage and linkage disequilibrium analyses pinpoint the ossification of the posterior
longitudinal ligament of the spine to COL6A1 locus on chromosome 21.
American Journal of Human Genetics 2003; 73, 812-822

59. Iwasaki K, Furukawa K-I, Tanno M, Kusumi M, Ueyama K, Tanaka M, Kudo H, Toh S, Harata S, Motomura S
Uni-axial cyclic stretch induces Cbfa1 expression in spinal ligament cells derived from patients with
ossification of posterior longitudinal ligaments.
Calcified Tissue International 2004; 74: 448-457

60. Taniguchi S, Furukawa K-I, Sasamura S, Ohizumi Y, Seya K, Motomura S
Gene expression and functional activity of sodium/calcium exchanger were enhanced in vascular
smooth muscle cells of spontaneously hypertensive rats.
Journal of Cardiovascular Pharmacology 2004; 43: 629-637

61. Miki I, Seya K, Motomura S and Furukawa K-I
Vasodilator Effects of Urocortin on Rat Aortae: Strain Difference in Contribution of Endothelium.
Journal of Pharmacological Science 2004; 96: 170-176

62. Ikeda R, Yoshida K, Tsukahara S, Sakamoto Y, Tanaka H, Furukawa K-I, Inoue I
PLZF promotes osteoblastic differentiation of human mesenchymal stem cells as an upstream regulator of CBFA1.
Journal of Biological Chemistry 2005; 280: 8523-8530

63. Seya K, Furukawa K-I Yoshida K, Narita R, Motomura S
Nifedipine enhances cGMP production through the activation of guanylyl cyclase in rat cardiac muscle.
Journal of Pharmacy and Pharmacology, 2005; 57: 511-514

64. Horai Y, Furukawa K-I, Iwata S, Ohizumi Y
pH change-induced increase in perfusion pressure of the rat coronary artery enhanced by elevation of blood pressure.
Journal of Pharmacological Science, 2005; 97: 400-407

65. Ashikaga K, Kobayashi T, Kimura M, Owada S, Sasaki S, Iwasa A, Furukawa K-I, Motomura S, Okumura K
Effects of amiodarone on electrical and structural remodeling induced in a canine rapid pacing-induced
persistent atrial fibrillation model.

　  European Journal of Pharmacology 2006; 536: 148–153

66. Tsukahara S, Ikeda R, Goto Shin, Yoshida K, Mitsumori R, Tajima A, Yokoyama T, Toh S,

　　Furukawa K-I, Inoue ITumor necrosis factor-a stimulated gene-6 inhibits osteoblastic differentiation

　　of human mesenchymal stem cells induced by OS and BMP-2.

　　Biochemical Journal 2006; 398: 595-603.

67. Iwasawa T, Iwasaki K, Okada A, Ueyama K, Motomura S, Harata S, Inoue I, Toh S and Furukawa K-I.
Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by
mechanical stress. Calcified Tissue International 2006; 79: 422-430

68. Seya S, Motomura S and Furukawa K-I
Cardiac mitochondrial cGMP stimulates cytochrome c release.
Clinical Science 2007; 112: 113-121

69. Kageyama K, Hanada K, Nigawara T, Furukawa K-I, Terui K, Ogura E, Motomura S, Suda T. 
Inhibitory effects of glucocorticoids on urocortin-mediated increases in interleukin-6 gene expression
in rat aortic smooth muscle cells.
Peptides 2007; 28: 1059-1067.

70. Daitoku K, Seya K, Furukawa K-I, and Motomura S.
Simultaneous Assessment of the Effects of Drugs on Each L- and N-Type Ca2+ Channel Using Canine
Isolated Blood-Perfused Papillary Muscle Preparation.
Tohoku Med J 2007; 212: 415-422

71.Abe K, Kushibiki T, Matsue H, Furukawa K-I, and Motomura S. Generation of Antitumor
Active Neutral Medium-Sized α-Glycan in Apple Vinegar Fermentation.

　  Bioscience, Biotechnology, and Biochemistry 2007; 71: 2124-2129

72. Sawada T, Kishiya M, Kanemaru K, Yokoyama T, Ueyama K, Motomura S, Toh S and Furukawa K-I
Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments.
Journal of Pharmacological Science 2008;106:152-161.

73. Kanemaru K, Seya K, Miki I, Motomura S and Furukawa K-I.
Calcification of aortic smooth muscle cells isolated from spontaneously hypertensive rats.
Journal of Pharmacological Science 2008; 106: 280-286.

74. Kishiya M, Sawada T, Kanemaru K, Kudo H, Numasawa T, Yokoyama T, Motomura S, Ueyama K,
Harata S, Toh S and Furukawa K-I
A functional RNAi screen for runx2-regulated genes corresponding to ectopic bone formation
in human spinal ligaments.
Journal of Pharmacological Science 2008; 106: 404-414.

75. Furukawa K-I. Pharmacological aspect of ectopic ossification in spinal ligament tissues.

      Pharmacology and Therapeutics 2008; 118: 352-358.

76. Ono T, Kawaguchi Y, Kudo M, Kushikata T, Hashiba E, Yoshida H, Kudo T, Furukawa K-I, Douglas SA,
Guerrini R, Calo G and Hirota K
Urotensin II evokes neurotransmitter release from rat cerebrocortical slices.
Neuroscience Letters 2008; 440: 275-279.

77. Kishiya M, Furukawa K-I, Yokoyama T, Kudo H, Ono A, Numasawa T, Wada K and Toh S.
Comparison of Cardiovascular Parameters between Patients with Ossification of Posterior Longitudinal
Ligament and Patients with Cervical Spondylotic Myelopathy.
Journal of Spinal Disorders & Techniques 2009 in press.

78. Tase R, Kushikata T, Yoshida H, Furukawa K-I, Ueno and Hirota K.
Orexin A decreases ketamine induced anesthesia time in the rat; Relevance to brain noradrenergic neuronal activity.
Anesthesia and Analgesia 2009 in press.

79. Seya K, Kanemaru K, Sugimoto C, Suzuki M, Takeo Teruko, Motomura S, Kitahara H, Niwa M, Oshima Y
and Furukawa K-I.
Opposite effects of two resveratrol tetramers, vitisin A and hopeaphenol on apoptosis of myocytes
isolated from adult rat heart. Journal of Pharmacology and Experimental Therapeutics, 2009 in press.

80. Kawaguchi Y, Ono T, Kudo M, Kushikata T, Hashiba E, Yoshida H, Kudo T, Furukawa K-I, Douglas SA,
Hirota K.
Effects of benzodiazepines on urotensin II stimulated norepinephrine release from rat cerebrocortical slices.
Anesthesia and Analgesia 2009 in press.

81. Niwa H, Sakai T, Furukawa K-I, Kanemaru K, Motomura S, Hirota K.
DNA Microarray Analysis of the Pro-inflammatory Gene Expression by Ketamine in C6 Cells.
Hirosaki Medical Journal 2009 in press.

 

 

 

 
 
               




 
 
 
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