ƒz[ƒ€@>@Œ¤‹†‹ÆÑ@>@2016”NE2017”NE2018”NE2019”NE2020”NE2021”NE2022”N@Œ¤‹†‹ÆÑ

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2022”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Iwamura H, Mizuno K, Akamatsu S, Hatakeyama S, Tobisawa Y, Narita S, Narita T, Yamashita S, Kawamura S, Sakurai T, Fujita N, Kodama H, Noro D, Kakizaki I, Nakaji S, Itoh K, Tsuchiya N, Ito A, Habuchi T, Ohyama C, Yoneyama T. Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases. Cancer Sci. 2022
  • Hasegawa T, Kakuta M, Yamaguchi R, Sato N, Mikami T, Murashita K, Nakaji S, Itoh K, Imoto S. Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population. Sci Rep. 2022 May 10;12(1):7628.
  • Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6):3201.
  • Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A. Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.J Hum Genet. 2022 Jan 17.

2021”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Wai KM, Kaori S, Itoh K, Shinya O, Uchikawa Y, Hayashi S, Shiraki A, Murashita K, Nakaji S, Ihara K. Telomere Length and Arterial Stiffness Reflected by Brachial-Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study. J Pers Med 2021 Dec 2;11(12):1278.
  • Nakahata N,Nakamura T, Kawarabayashi T, Seino Y, Ichii S, Ikeda Y, Amari M, Takatama M, Murashita K, Ihara K, Itoh K, Nakaji S, Shoji M. Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project. J Alzheimers Dis 2021;84(3):1233-1245.
  • Zhang A, Suzuki T, Adachi S, Naganuma E, Suzuki N, Hosoya T, Itoh K, Sporn MB, Yamamoto M. Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction. Mol Cell Biol. 2021 Aug 16:MCB0023621
  • Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T. Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis. Biochem Biophys Rep. 2021 Aug 12;27:101101.
  • Dorion M-F, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H. The CD36 ligand-promoted autophagy protects retinal pigment epithelial cells from oxidative stress. Oxid Med Cell Longev 6691402, 2021.
  • Matsumoto M, Suganuma H, Ozato N, Shimizu S, Katashima M, Katsuragi Y, Mikami T, Itoh Ken, Nakaji S. Association between Serum Concentration of Carotenoid and Visceral Fat. Nutrients 13(3):912, 2021.
  • Nakamura K, Kojima R, Uchino E, Ono K, Yanagita M, Murashita K, Itoh K, Nakaji S, Okuno Y. Health improvement framework for actionable treatment planning using a surrogate Bayesian model. Nat Commun 12(1):3088, 2021.
  • Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S, Ichihara G. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology 456:152785, 2021.
  • Yamamoto H, Suzuki M, Matsuta R, Sasaki K, Kang MI, Kami K, Tatara Y, Itoh K, Nakaji S. Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study. Metabolites 11(5):314, 2021.
  • Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T. Characterization of mitochondrial calpain-5. Biochim Biophys Acta Mol Cell Res 1868(5):118989, 2021.

2020”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • ˆÉ“ŒŒ’ALiu JunAŠ‹¼H‘î.–«t‘Ÿ•a‚É‚¨‚¯‚éNrf2-Keap1Œo˜H‚Ì–ðŠ„-CKDŽ¡—Öò‚Æ‚µ‚Ä‚ÌŠú‘Ò.—Տ°“§Í36, 35-41, 2020.
  • Mate Janos Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh. JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis. FEBS Open Bio 10(12):2771-2779, 2020.
  • Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K.@Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Biomolecules. 2020 Feb 17;10(2):320
  • Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.@PLoS Genet. 2020 Apr 23;16(4):e1008693.
  • Yokono Y, Hanada K,@Narita@M, Tatara@Y,@Kawamura@Y,@Miura@N,@Kitayama@K,@Nakata@M, Nozaka@M,@Kato@T,@Kodo@N,@Tsushima@M,@Toyama@Y,@Itoh@K,@Tomita@H.@Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice. J Am Heart Assoc. e015616, 2020.
  • Yamazaki H., Itoh K.(2020) Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation. In: Deng H.(eds) Nrf2 and its Modulation in Inflammation. Progress in Inflammation Research, vol 85.Springer,@Cham DOI:10.1007/978-3-030-44599-7_4
  • ŽO‘ºƒ³AˆÉ“ŒŒ’. ƒtƒ@ƒCƒgƒPƒ~ƒJƒ‹‚É‚æ‚éKeap1-Nrf2Œo˜H‚ÌŠˆ«‰». ŽÀŒ±ˆãŠw 38(10) 99-105, 2020.
  • Š‹¼H‘îA´…’¼A‘½“c—…—m‘¾AŽO‘ºƒ³AˆÉ“ŒŒ’. ƒXƒgƒŒƒX‰ž“š«“]ŽÊˆöŽqNrf2‚ÆATF4‚Ì‘ŠŒÝì—p‚ðŠî”Õ‚É‚µ‚½Ž¾Š³—\–hEƒAƒ“ƒ`ƒGƒCƒWƒ“ƒO–@‚ÌŠJ”­. BIO Clinica 35(10):60-64, 2020.
  • Maeda Y, Sasaki A, Kasai S, Goto S, Nishio S, Sawada K, Tokuda I, Itoh K, Usami S, Matsubara A. Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan. Human Genome Variation 7(1):27, 2020
  • Matsumoto M, Waki N, Suganuma H, Takahashi I, Kurauchi S, Sawada K, Tokuda I, Misawa M, Ando M, Itoh K, Ihara K, Nakaji S. Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness. Nutrients. 2020 Jul 31;12(8):E2310.
  • Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K. Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging. PLoS One. 2020 Aug 11;15(8):e0236834.

2019”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Sehsah R, Wu W, Ichihara S, Hashimoto N, Hasegawa Y, Zong C, Itoh K, Yamamoto M, Elsayed AA, El-Bestar, Kamel E, Ichihara G. Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles. Part Fibre Toxicol 16(1):47, 2019.
  • Kasai S, Yamazaki H, Tanji K, Mate Janos Engler, Matsumiya T, Itoh K. Role of ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control. J Clin Biochem Nutr 2019;64:1-12.
  • Suto A, Kudo D, Yoshida E, Nagase H, Suto S, Mimura J, Itoh K, Hakamada K. Increase of Tumor Infiltrating ƒÁƒÂT-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone. Pancreas. 2019;48:292-298.
  • ˆÉ“ŒŒ’A•½”öqA‰Á“¡‹±äAŽO‘ºƒ³AŠ‹¼H‘î. Nrf2‚ÆATF4‚Ì‘ŠŒÝì—p‚É’…–Ú‚µ‚½Ž¾Š³—\–hEƒAƒ“ƒ`ƒGƒCƒWƒ“ƒO–@‚ÌŠJ”­. Medical Science Digest 45:56-59, 2019.
  • Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes. Int J Mol Sci 20(7):1706, 2019.
  • Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K. Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.@Arch Pharm Res. 2020 Mar;43(3):286-296.

2018”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. Sci Rep 2018;8:8037.
  • Nakamura T, Kawarabayashi T, Seino Y, Hirohata M, Nakahara N, Narita S, Itoh K, Nakaji S, Shoji M. Aging and APOE-e4 are determinative factors of plasma Ab42 levels. Annals Clin. Trans. Neurol. 2018;5:1184-1191.
  • Kasai S, Mimura J, Ozaki T, Itoh K. Emerging regulatory role of Nrf2 in iron, heme and hemoglobin metabolism in physiology and disease. Front.Vet Sci 2018;5:242.
  • ˆÉ“ŒŒ’. ƒxƒCƒ“ƒYEƒhƒ~ƒjƒ`ƒƒƒN¶‰»Šw. ŠÛ‘Po”Å. ‘æ35Í–|–ó’S“–.@

2017”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Kasai S, Richardson M. J. E., Torii S, Yasumoto K, Shima H, Igarashi K, Itoh K, Sogawa K, Murayama K. Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS J 2017;284:4115-4127.
  • K.Tatara Y, Suto S, Itoh K. Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin. Glycobiology.2017;27:1089-1098.
  • Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J 2017;31:4011-4022.
  • ŽO‘ºƒ³AˆÉ“ŒŒ’DNrf2ƒVƒXƒeƒ€‚É‚æ‚鐶‘Ì–hŒä‰ž“šD—Տ°–ƉuEƒAƒŒƒ‹ƒM[‰ÈC2017;67(6):642-648.
  • ŽR›½”Ž–¢AEngler Mate JanosAˆÉ“ŒŒ’. Nrf2‚̍R˜V‰»ˆöŽq‚Æ‚µ‚Ä‚Ì–ðŠ„.@‘æ37‰ñ‘‰ïƒVƒ“ƒ|ƒWƒEƒ€‚Ru˜V‰»‚ƏzŠÂ§ŒävC2017;21-33.

2016”N@Œ¤‹†‹ÆÑ

y ˜_ •¶ z

  • Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. The role of NUB1 in ƒ¿-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016;470:635-642.
  • Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T. The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects in combination with quinone-containing compounds and anti-microtubule drugs. Oncotarget.2016;7:79217-79232.