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研究業績

2023年　研究業績

【 論 文 】

  • Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment. Curr Res Transl Med 71, 103367, 2023.
  • Inose-Maruyama A, Kasai S, Itoh K. Human Heme Oxygenase-1 Promoter Activity Is Mediated by Z-DNA Formation. Methods Mol Biol 2651, 157-166, 2023.
  • Nakamura T, Kawarabayashi T, Ueda T, Shimomura S, Hoshino M, Itoh K, Ihara K, Nakaji S, Takatama M, Ikeda Y, Shoji M. Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer's Disease. J Alzheimer’s Dis 93, 333-348, 2023.
  • Fuke N, Yamashita T, Shimizu S, Matsumoto M, Sawada K, Jung S, Tokuda I, Misawa M, Suzuki S, Ushida Y, Mikami T, Itoh K, Suganuma H. Association of Plasma Lipopolysaccharide-Binding Protein Concentration with Dietary Factors, Gut Microbiota, and Health Status in the Japanese General Adult Population: A Cross-Sectional Study. Metabolites 13, 250, 2023.
  • Yamauchi T, Koyama N, Hirai A, Suganuma H, Suzuki S, Murashita K, Mikami T, Tamada Y, Sato N, Imoto S, Itoh K, Nakaji S. Definition of a Dietary Pattern Expressing the Intake of Vegetables and Fruits and Its Association with Intestinal Microbiota. Nutrients 15, 2104, 2023.
  • Ito G, Tatara Y, Itoh K, Yamada M, Yamashita T, Sakamoto K, Nozaki T, Ishida K, Wake Y, Kaneko T, Fukuda T, Sugano E, Tomita H, Ozaki T. Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity. BBA Adv 3, 100092, 2023.
  • Kawarabayashi T, Nakahata N, Itoh K, Ihara K, Nakaji S, Ikeda Y, Takatama M, Shoji M. Annual stability of the plasma A?40/42 ratio and associated factors. Ann Clin Transl Neurol 10, 879-891, 2023.
  • Fujita N, Ishida M, Iwane T, Suganuma H, Matsumoto M, Hatakeyama S, Yoneyama T, Hashimoto Y, Mikami T, Itoh K, Ohyama C. Association between Advanced Glycation End-Products, Carotenoids, and Severe Erectile Dysfunction. World J Mens Health 41, 701-711, 2023.
  • Nakamura K, Uchino E, Sato N, Araki A, Terayama K, Kojima R, Murashita K, Itoh K, Mikami T, Tamada Y, Okuno Y. Individual health-disease phase diagrams for disease prevention based on machine learning. J Biomed Inform 144, 104448, 2023.
  • Kimura Y, Ekuban FA, Zong C, Sugie S, Zhang X, Itoh K, Yamamoto M, Ichihara S, Ohsako S, Ichihara G. Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver. Toxicol Sci. 195, 28-41, 2023.
  • Sato M, Wai KM, Itoh K, Yang Y, Uchikawa Y, Ito Y, Nakaji S, Ihara K. Does the Protective Effect of Zinc on Telomere Length Depend on the Presence of Hypertension or Type 2 Diabetes? Results from the Iwaki Health Promotion Project, Japan. Nutrients 15, 4373, 2023.
  • Kasai S, Kokubu D, Mizukami H, Itoh K. Mitochondrial Reactive Oxygen Species, Insulin Resistance, and Nrf2-Mediated Oxidative Stress Response-Toward an Actionable Strategy for Anti-Aging. Biomolecules 13, 1544, 2023.
  • Yokoyama M, Fujita T, Kadonosawa Y, Tatara Y, Motooka D, Ikawa M, Fujii H, Yokoayama Y. Development of transgenic mice overexpressing mouse carbonyl reductase 1. Mol Biol Rep 50, 531-540, 2023.
  • Tatara Y, Monzen S. Proteomics and secreted lipidomics of mouse-derived bone marrow cells exposed to a lethal level of ionizing radiation. Sci Rep 13, 8802, 2023.
  • Kubota S, Miura T, Wakiya T, Yoshizawa T, Goto S, Morohashi H, Sakamoto Y, Tatara Y, Kijima H, Hakamada K. ASO Visual Abstract: Exploration of Malignant Characteristics in Neoadjuvant Chemotherapy-Resistant Rectal Cancer, Focusing on Extramural Lesions. Ann Surg Oncol 30, 7639-7640, 2023.
  • Kubota S, Miura T, Wakiya T, Yoshizawa T, Goto S, Morohashi H, Sakamoto Y, Tatara Y, Kijima H, Hakamada K. Exploration of Malignant Characteristics in Neoadjuvant Chemotherapy-Resistant Rectal Cancer, Focusing on Extramural Lesions. Ann Surg Oncol 30, 7612-7623, 2023.
  • Li S, Wang X, Tatara Y, Hamada S, Kozeki T, Kojima K, Yoshida T. Purification and characterization of hyaluronate lyases produced by two types of bacteria. Agricultural Biotechnology 12, 99-104, 2023.

2022年　研究業績

【 論 文 】

  • Shimizu S, Kasai S, Yamazaki H, Tatara Y, Mimura J, Engler MJ, Tanji K, Nikaido Y, Inoue T, Suganuma H, Wakabayashi K, Itoh K. Sulforaphane Increase Mitochondrial Biogenesis-Related Gene Expression in the Hippocampus and Suppresses Age-Related Cognitive Decline in Mice. Int J Mol Sci. 23, 8433, 2022.
  • Sehsah R, Wu W, Ichihara S, Hashimoto N, Zong C, Yamazaki K, Sato H, Itoh K, Yamamoto M, Elsayed AA, El-Bestar S, Kamel E, Ichihara G. Protective role of Nrf2 in zinc oxide nanoparticles-induced lung inflammation in female mice and sexual dimorphism in susceptibility. Toxicol Lett. 370:24-34, 2022.
  • Tatara Y, Yamazaki H, Katsuoka F, Chiba M, Saigusa D, Kasai S, Nakamura T, Inoue J, Aoki Y, Shoji M, Motoike IN, Tamada Y, Hashizume K, Shoji M, Kinoshita K, Murashita K, Nakaji S, Yamamoto M, Itoh K. Multiomics and artificial intelligence enabled peripheral blood-based prediction of amnestic mild cognitive impairment. Curr Res Transl Med. 71, 103367, 2022.
  • Iwamura H, Mizuno K, Akamatsu S, Hatakeyama S, Tobisawa Y, Narita S, Narita T, Yamashita S, Kawamura S, Sakurai T, Fujita N, Kodama H, Noro D, Kakizaki I, Nakaji S, Itoh K, Tsuchiya N, Ito A, Habuchi T, Ohyama C, Yoneyama T. Machine learning diagnosis by immunoglobulin N-glycan signatures for precision diagnosis of urological diseases. Cancer Sci. Jul;113(7):2434-2445, 2022.
  • Hasegawa T, Kakuta M, Yamaguchi R, Sato N, Mikami T, Murashita K, Nakaji S, Itoh K, Imoto S. Impact of salivary and pancreatic amylase gene copy numbers on diabetes, obesity, and functional profiles of microbiome in Northern Japanese population. Sci Rep. 2022 May 10;12(1):7628.
  • Liu J, Kasai S, Tatara Y, Yamazaki H, Mimura J, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Tanji K, Wakabayashi K, Maeda H, Mizukami H, Shinkai Y, Kumagai Y, Tomita H, Itoh K. Inducible Systemic Gcn1 Deletion in Mice Leads to Transient Body Weight Loss upon Tamoxifen Treatment Associated with Decrease of Fat and Liver Glycogen Storage. Int J Mol Sci. 2022 Mar 16;23(6):3201.
  • Miura S, Sasaki A, Kasai S, Sugawara T, Maeda Y, Goto S, Kasai T, Shimizume N, Jung S, Iwane T, Itoh K, Matsubara A. Association of mitochondrial DNA haplogroup and hearing impairment with aging in Japanese general population of the Iwaki Health Promotion Project.J Hum Genet. Jun;67(6):369-751, 2022.

2021年　研究業績

【 論 文 】

  • Wai KM, Kaori S, Itoh K, Shinya O, Uchikawa Y, Hayashi S, Shiraki A, Murashita K, Nakaji S, Ihara K. Telomere Length and Arterial Stiffness Reflected by Brachial-Ankle Pulse Wave Velocity: A Population-Based Cross-Sectional Study. J Pers Med 2021 Dec 2;11(12):1278.
  • Nakahata N,Nakamura T, Kawarabayashi T, Seino Y, Ichii S, Ikeda Y, Amari M, Takatama M, Murashita K, Ihara K, Itoh K, Nakaji S, Shoji M. Age-Related Cognitive Decline and Prevalence of Mild Cognitive Impairment in the Iwaki Health Promotion Project. J Alzheimers Dis 2021;84(3):1233-1245.
  • Zhang A, Suzuki T, Adachi S, Naganuma E, Suzuki N, Hosoya T, Itoh K, Sporn MB, Yamamoto M. Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction. Mol Cell Biol. 2021 Aug 16:MCB0023621
  • Sugawara M, Abe T, Kasai S, Itoh K, Ozaki T. Calpain-1 C2L domain peptide protects mouse hippocampus-derived neuronal HT22 cells against glutamate-induced oxytosis. Biochem Biophys Rep. 2021 Aug 12;27:101101.
  • Dorion M-F, Mulumba M, Kasai S, Itoh K, Lubell WD, Ong H. The CD36 ligand-promoted autophagy protects retinal pigment epithelial cells from oxidative stress. Oxid Med Cell Longev 6691402, 2021.
  • Matsumoto M, Suganuma H, Ozato N, Shimizu S, Katashima M, Katsuragi Y, Mikami T, Itoh Ken, Nakaji S. Association between Serum Concentration of Carotenoid and Visceral Fat. Nutrients 13(3):912, 2021.
  • Nakamura K, Kojima R, Uchino E, Ono K, Yanagita M, Murashita K, Itoh K, Nakaji S, Okuno Y. Health improvement framework for actionable treatment planning using a surrogate Bayesian model. Nat Commun 12(1):3088, 2021.
  • Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S, Ichihara G. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology 456:152785, 2021.
  • Yamamoto H, Suzuki M, Matsuta R, Sasaki K, Kang MI, Kami K, Tatara Y, Itoh K, Nakaji S. Capillary Electrophoresis Mass Spectrometry-Based Metabolomics of Plasma Samples from Healthy Subjects in a Cross-Sectional Japanese Population Study. Metabolites 11(5):314, 2021.
  • Chukai Y, Iwamoto T, Itoh K, Tomita H, Ozaki T. Characterization of mitochondrial calpain-5. Biochim Biophys Acta Mol Cell Res 1868(5):118989, 2021.

2020年　研究業績

【 論 文 】

  • 伊東健、Liu Jun、葛西秋宅.慢性腎臓病におけるNrf2-Keap1経路の役割-CKD治療薬としての期待.臨床透析36, 35-41, 2020.
  • Mate Janos Engler, Junsei Mimura, Shun Yamazaki, Ken Itoh. JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis. FEBS Open Bio 10(12):2771-2779, 2020.
  • Kasai S, Shimizu S, Tatara Y, Mimura J, Itoh K.　Regulation of Nrf2 by Mitochondrial Reactive Oxygen Species in Physiology and Pathology. Biomolecules. 2020 Feb 17;10(2):320
  • Yamazaki H, Kasai S, Mimura J, Ye P, Inose-Maruyama A, Tanji K, Wakabayashi K, Mizuno S, Sugiyama F, Takahashi S, Sato T, Ozaki T, Cavener DR, Yamamoto M, Itoh K. Ribosome binding protein GCN1 regulates the cell cycle and cell proliferation and is essential for the embryonic development of mice.　PLoS Genet. 2020 Apr 23;16(4):e1008693.
  • Yokono Y, Hanada K,　Narita　M, Tatara　Y,　Kawamura　Y,　Miura　N,　Kitayama　K,　Nakata　M, Nozaka　M,　Kato　T,　Kodo　N,　Tsushima　M,　Toyama　Y,　Itoh　K,　Tomita　H.　Blockade of PAR-1 Signaling Attenuates Cardiac Hypertrophy and Fibrosis in Renin-Overexpressing Hypertensive Mice. J Am Heart Assoc. e015616, 2020.
  • Yamazaki H., Itoh K.(2020) Nrf2 in the Regulation of Endothelial Cell Homeostasis During Inflammation. In: Deng H.(eds) Nrf2 and its Modulation in Inflammation. Progress in Inflammation Research, vol 85.Springer,　Cham DOI:10.1007/978-3-030-44599-7_4
  • 三村純正、伊東健. ファイトケミカルによるKeap1-Nrf2経路の活性化. 実験医学 38(10) 99-105, 2020.
  • 葛西秋宅、清水直、多田羅洋太、三村純正、伊東健. ストレス応答性転写因子Nrf2とATF4の相互作用を基盤にした疾患予防・アンチエイジング法の開発. BIO Clinica 35(10):60-64, 2020.
  • Maeda Y, Sasaki A, Kasai S, Goto S, Nishio S, Sawada K, Tokuda I, Itoh K, Usami S, Matsubara A. Prevalence of the mitochondrial 1555 A>G and 1494 C>T mutations in a community-dwelling population in Japan. Human Genome Variation 7(1):27, 2020
  • Matsumoto M, Waki N, Suganuma H, Takahashi I, Kurauchi S, Sawada K, Tokuda I, Misawa M, Ando M, Itoh K, Ihara K, Nakaji S. Association between Biomarkers of Cardiovascular Diseases and the Blood Concentration of Carotenoids among the General Population without Apparent Illness. Nutrients. 2020 Jul 31;12(8):E2310.
  • Shimizu S, Mimura J, Hasegawa T, Shimizu E, Imoto S, Tsushima M, Kasai S, Yamazaki H, Ushida Y, Suganuma H, Tomita H, Yamamoto M, Nakaji S, Itoh K. Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging. PLoS One. 2020 Aug 11;15(8):e0236834.

2019年　研究業績

【 論 文 】

  • Sehsah R, Wu W, Ichihara S, Hashimoto N, Hasegawa Y, Zong C, Itoh K, Yamamoto M, Elsayed AA, El-Bestar, Kamel E, Ichihara G. Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles. Part Fibre Toxicol 16(1):47, 2019.
  • Kasai S, Yamazaki H, Tanji K, Mate Janos Engler, Matsumiya T, Itoh K. Role of ISR-ATF4 pathway and its cross talk with Nrf2 in mitochondrial quality control. J Clin Biochem Nutr 2019;64:1-12.
  • Suto A, Kudo D, Yoshida E, Nagase H, Suto S, Mimura J, Itoh K, Hakamada K. Increase of Tumor Infiltrating γδT-cells in Pancreatic Ductal Adenocarcinoma Through Remodeling of the Extracellular Matrix by a Hyaluronan Synthesis Suppressor, 4-Methylumbelliferone. Pancreas. 2019;48:292-298.
  • 伊東健、平尾航、加藤恭丈、三村純正、葛西秋宅. Nrf2とATF4の相互作用に着目した疾患予防・アンチエイジング法の開発. Medical Science Digest 45:56-59, 2019.
  • Mimura J, Inose-Maruyama A, Taniuchi S, Kosaka K, Yoshida H, Yamazaki H, Kasai S, Harada N, Kaufman RJ, Oyadomari S, Itoh K. Concomitant Nrf2- and ATF4-activation by carnosic acid cooperatively induces expression of cytoprotective genes. Int J Mol Sci 20(7):1706, 2019.
  • Tsushima M, Liu J, Hirao W, Yamazaki H, Tomita H, Itoh K. Emerging evidence for crosstalk between Nrf2 and mitochondria in physiological homeostasis and in heart disease.　Arch Pharm Res. 2020 Mar;43(3):286-296.

2018年　研究業績

【 論 文 】

  • Dayalan Naidu S, Muramatsu A, Saito R, Asami S, Honda T, Hosoya T, Itoh K, Yamamoto M, Suzuki T, Dinkova-Kostova AT. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape. Sci Rep 2018;8:8037.
  • Nakamura T, Kawarabayashi T, Seino Y, Hirohata M, Nakahara N, Narita S, Itoh K, Nakaji S, Shoji M. Aging and APOE-e4 are determinative factors of plasma Ab42 levels. Annals Clin. Trans. Neurol. 2018;5:1184-1191.
  • Kasai S, Mimura J, Ozaki T, Itoh K. Emerging regulatory role of Nrf2 in iron, heme and hemoglobin metabolism in physiology and disease. Front.Vet Sci 2018;5:242.
  • 伊東健. ベインズ・ドミニチャク生化学. 丸善出版. 第35章翻訳担当.　

2017年　研究業績

【 論 文 】

  • Kasai S, Richardson M. J. E., Torii S, Yasumoto K, Shima H, Igarashi K, Itoh K, Sogawa K, Murayama K. Increase in proapoptotic activity of inhibitory PAS domain protein via phosphorylation by MK2. FEBS J 2017;284:4115-4127.
  • K.Tatara Y, Suto S, Itoh K. Novel roles of glycosaminoglycans in the degradation of type I collagen by cathepsin. Glycobiology.2017;27:1089-1098.
  • Sakai E, Morita M, Ohuchi M, Kido MA, Fukuma Y, Nishishita K, Okamoto K, Itoh K, Yamamoto M, Tsukuba T. Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis. FASEB J 2017;31:4011-4022.
  • 三村純正、伊東健．Nrf2システムによる生体防御応答．臨床免疫・アレルギー科，2017;67(6):642-648.
  • 山嵜博未、Engler Mate Janos、伊東健. Nrf2の抗老化因子としての役割.　第37回総会シンポジウム３「老化と循環制御」，2017;21-33.

2016年　研究業績

【 論 文 】

  • Tanji K, Miki Y, Maruyama A, Mori F, Mimura J, Itoh K, Kamitani T, Wakabayashi K. The role of NUB1 in α-synuclein degradation in Lewy body disease model mice. Biochem Biophys Res Commun. 2016;470:635-642.
  • Liu PY, Sokolowski N, Guo ST, Siddiqi F, Atmadibrata B, Telfer TJ, Sun Y, Zhang L, Yu D, Mccarroll J, Liu B, Yang RH, Guo XY, Tee AE, Itoh K, Wang J, Kavallaris M, Haber M, Norris MD, Cheung BB, Byrne JA, Ziegler DS, Marshall GM, Dinger ME, Codd R, Zhang XD, Liu T. The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects in combination with quinone-containing compounds and anti-microtubule drugs. Oncotarget.2016;7:79217-79232.