弘前大学大学院医学研究科　呼吸器内科学講座

研究業績

2019年度研究業績

2018年度研究業績

2017年度研究業績

2016年度以前

2018年研究業績

1. Sakamoto H, Tanaka H, Shiratori T, Baba K, Ishioka Y, Itoga M, Taima K, Hasegawa Y, Takanashi S, Tasaka S. The efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer harboring driver mutations. Mol Clin Oncol. (in press)
2. Namkoong H, Ishii M, Fujii H, Yagi K, Asami T, Asakura T, Suzuki S, Kamata H, Tasaka S, Hasegawa N, Koyasu S, Betsuyaku T. Clarithromycin expands CD11b+Gr-1+ cells via the STAT3/Bv8 axis to ameliorate lethal endotoxic shock and post-influenza bacterial pneumonia. PLoS Pathog. 14: e1006955, 2018. doi: 10.1371/journal.ppat.1006955.
3. Tanaka H, Taima K, Tanaka Y, Itoga M, Ishioka Y, Morimoto T, Nakagawa H, Baba K, Hasegawa Y, Takanashi S, Tasaka S. A phase I study of afatinib for patients aged 75 or older with advanced non-small cell lung cancer harboring EGFR mutations. Med Oncol. 35: 34, 2018. doi: 10.1007/s12032-018-1098-3.
4. Asami T, Ishii M, Namkoong H, Yagi K, Tasaka S, Asakura T, Suzuki S, Kamo T, Okamori S, Kamata H, Zhang H, Hegab AE, Hasegawa N, Betsuyaku T. Anti-inflammatory roles of mesenchymal stromal cells during acute Streptococcus pneumoniae pulmonary infection in mice. Cytotherapy 20: 302-313, 2018. doi: 10.1016/j.jcyt.2018.01.003.
5. Tasaka S. Acute pulmonary infiltrates in patients with rheumatoid arthritis: Differential diagnosis and management. ed., Gono T, Tokuda H, Sakai F, Takemura T. Lung disease associated with rheumatoid arthritis. pp. 187-199, Springer, Singapore, 2018.
6. Tanaka Y, Taima K, Tanaka H, Itoga M, Ishioka Y, Shiratori T, Tsuchiya J, Sakamoto H, Takanashi S, Tasaka S. Emergency radiotherapy for spinal cord compression due to bone sarcoidosis. Intern Med. 57: 717-720, 2018.
7. Ko R, Shukuya T, Okuma Y, Tateishi K, Imai H, Iwasawa S, Miyauchi E, Fujiwara A, Sugiyama T, Azuma K, Muraki K, Yamasaki M, Tanaka H, Takashima Y, Soda S, Ishimoto O, Koyama N, Morita S, Kobayashi K, Nukiwa T, Takahashi K; North East Japan Study Group　Prognostic Factors and Efficacy of First-Line Chemotherapy in Patients with Advanced Thymic Carcinoma: A Retrospective Analysis of 286 Patients from NEJ023 Study.　Oncologist. 2018 Oct;23(10):1210-1217.
8. Asakura T, Ishii M, Namkoong H, Suzuki S, Kagawa S, Yagi K, Komiya T, Hashimoto T, Okamori S, Kamata H, Tasaka S, Kihara A, Hegab AE, Hasegawa N, Betsuyaku T. Sphingosine 1-phosphate receptor modulator ONO-4641 stimulates CD11b+Gr-1+ cell expansion and inhibits lymphocyte infiltration in the lungs to ameliorate murine pulmonary emphysema. Mucosal Immunol. 2018 Nov;11(6):1606-1620. doi: 10.1038/s41385-018-0077-5.
9. Imaizumi T, Sassa N, Kawaguchi S, Matsumiya T, Yoshida H, Seya K, Shiratori T, Hirono K, Tanaka H. Interferon-stimulated gene 60 (ISG60) constitutes a negative feedback loop in the downstream of TLR3 signaling in hCMEC/D3 cells. Journal of Neuroimmunology, 324:16-21, Nov 15 2018.
10. Baba K, Tanaka H, Sakamoto H, Shiratori T, Tsuchiya J, Ishioka Y, Itoga M, Taima K, Tasaka S. The efficacy of pembrolizumab for patient with both high PD-L1 expression and MET exon 14 skipping mutation: A case report. Thorac Cancer. 2019 Jan 2. doi: 10.1111/1759-7714.12939.
11. Okuma Y, Morikawa K, Tanaka H, Yokoyama T, Itani H, Horiuchi K, Nakagawa H, Takahashi N, Bessho A, Soejima K, Kishi K, Togashi A, Kanai Y, Ueda K, Horimoto K, Matsutani N, Seki N.　Prospective exosome-focused translational research for afatinib study of non-small cell lung cancer patients expressing EGFR (EXTRA study).　Thorac Cancer. 2019 Feb;10(2):395-400.
12. Kamo T, Tasaka S, Suzuki T, Asakura T, Suzuki S, Yagi K, Namkoong H, Ishii M, Morisaki H, Betsuyaku T. Prognostic values of the Berlin definition criteria, blood lactate level, and fibroproliferative changes on high-resolution computed tomography in ARDS patients. BMC Pulm Med. 2019 Feb 11;19(1):37. doi: 10.1186/s12890-019-0803-0.
13. 土屋純一郎，田中寿志，當麻景章，中村琢洋，髙梨信吾，田坂定智．脊髄炎，感覚性軸索型ニューロパチーを呈した傍腫瘍性神経症候群の1例．日呼吸誌 7: 212-215, 2018.
14. 石岡佳子，當麻景章，糸賀正道，坂本博昭，掛端伸也，田坂定智．肺動脈と交通しmosaic attenuationを呈した縦隔型気管支動脈瘤．日呼吸誌 8: 72-75, 2019.
15. 藤井沙弥佳，城田 農，笠松裕貴，田辺つばさ，稲村隆夫，岡部孝裕，田坂定智．上気道における粒子付着の数値シミュレーション．混相流 32: 132-139, 2018.
16. 田坂定智．胸膜炎．福井次矢，高木 誠，小室一成 編．今日の治療指針 2019．p.335-336，医学書院，東京，2019.
17. 田坂定智．インフルエンザ合併症の治療 呼吸不全への対応．臨牀と研究95: 1225-1228, 2018.
18. 田坂定智．ARDS．呼吸器内科 34〔Suppl. 1〕呼吸器内科診療マニュアル: 492-498, 2018.
19. 田坂定智．劇症型肺炎．THE LUNG perspectives 26: 150-154, 2018.
20. 田坂定智．ARDSに対するステロイド，シベレスタット，抗凝固薬のエビデンス．長瀬洋之 編．呼吸器疾患の薬物療法を極める．p.282-286, 文光堂, 東京, 2018.
21. 田坂定智．ARDSの病態と疾患フェノタイプ．呼吸器内科 33: 1-8, 2018.
22. 田坂定智．ショックとARDS：病態の解明から治療応用へ．Shock 32: 2-4, 2018.