Hirosaki　University Graduate School Of Medicine Department of Microbiology and Immunology

ARTICLE

研究実績

2025年
1. Subsomwong, P., Asano, K., Akada, J., Matsumoto, T., Nakane, A., & Yamaoka, Y. (2025). Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer. Helicobacter, 30(2), e70022. https://doi.org/10.1111/hel.70022
2. Fukushi, R., Narita, K., Yamane, K., Koi, T., Asano, K., Nakane, A. (2025). Reactive oxygen species are involved in inhibition of photoreactivation of Staphylococcus aureus irradiated with 222-nm Far ultraviolet C. Photochem Photobiol, https://doi.org/10.1111/php.14065
3. Narita, K., Fukushi, R., Yamane, K., Okumura, Y., Koi, T., Asano, K., Nakane, A. (2025). Reactive oxygen species generated by irradiation with bandpass-filtered 222-nm Far-UVC play an important role in the germicidal mechanism to Escherichia coli. Appl Environ Microbiol, ;91(2):e0188624. https://doi.org/10.1128/aem.01886-24
4. Watabe, N., Subsomwong, P., Yamane, K., Asano, K., & Nakane, A. (2025). Polygonum tinctorium extract suppresses the virulence of methicillin-resistant Staphylococcus aureus by disrupting its extracellular vesicles. Journal of ethnopharmacology, 337(Pt 3), 118933. https://doi.org/10.1016/j.jep.2024.118933
2024年
1. 【著書】Nakane, A. and Asano, K. (2024). Staphylococcus aureus: Interplay between Bacteria and Hosts. Springer Nature Singapore Pte Ltd., Vll, 203. https://doi.org/10.1007/978-981-99-9428-1
2. Teng, W., Subsomwong, P., Narita, K., Nakane, A., & Asano, K. (2024). Heat Shock Protein SSA1 Enriched in Hypoxic Secretome of Candida albicans Exerts an Immunomodulatory Effect via Regulating Macrophage Function. Cells, 13(2), 127. https://doi.org/10.3390/cells13020127
3. Subsomwong, P., Teng, W., Ishiai, T., Narita, K., Sukchawalit, R., Nakane, A., & Asano, K. (2024). Extracellular vesicles from Staphylococcus aureus promote the pathogenicity of Pseudomonas aeruginosa. Microbiological research, 281, 127612. https://doi.org/10.1016/j.micres.2024.127612
4. Nakane, A., Hirose, S., Kawai, N., Fujimoto, N., Kondo, E., & Asano, K. (2024). Salmon nasal cartilage proteoglycan stimulates hair growth. Bioscience, biotechnology, and biochemistry, 88(1), 107–110. https://doi.org/10.1093/bbb/zbad149
2023年
1. Fukutoku, Y., Kikuchi, H., Hoshi, K., Narita, K., Asari, T., Miyazawa, K., Sawada, Y., Hayamizu, S., Tatsuta, T., Oota, S., Hasui, K., Hiraga, H., Chinda, D., Mikami, T., Subsomwong, P., Asano, K., Yamane, K., Ogawa, Y., Sasaki, M., Koi, T., … Sakuraba, H. (2023). The new 222-nm far ultraviolet-C lowers bacterial contamination to endoscopists during esophagogastroduodenoscopy. DEN open, 4(1), e292. https://doi.org/10.1002/deo2.292
2. Hiraga, H., Chinda, D., Maeda, T., Murai, Y., Ogasawara, K., Muramoto, R., Ota, S., Hasui, K., Sakuraba, H., Ishiguro, Y., Yoshida, S., Asano, K., Nakane, A., & Fukuda, S. (2023). Vitamin A Promotes the Fusion of Autophagolysosomes and Prevents Excessive Inflammasome Activation in Dextran Sulfate Sodium-Induced Colitis. International journal of molecular sciences, 24(10), 8684. https://doi.org/10.3390/ijms24108684
3. Fauzia, K. A., Aftab, H., Miftahussurur, M., Waskito, L. A., Tuan, V. P., Alfaray, R. I., Matsumoto, T., Yurugi, M., Subsomwong, P., Kabamba, E. T., Akada, J., & Yamaoka, Y. (2023). Genetic determinants of Biofilm formation of Helicobacter pylori using whole-genome sequencing. BMC microbiology, 23(1), 159. https://doi.org/10.1186/s12866-023-02889-8
4. Ishiai, T., Subsomwong, P., Narita, K., Kawai, N., Teng, W., Suzuki, S., Sukchawalit, R., Nakane, A., & Asano, K. (2023). Extracellular vesicles of Pseudomonas aeruginosa downregulate pyruvate fermentation enzymes and inhibit the initial growth of Staphylococcus aureus. Current research in microbial sciences, 4, 100190. https://doi.org/10.1016/j.crmicr.2023.100190
5. Suzuki, S., Subsomwong, P., Narita, K., Kawai, N., Ishiai, T., Teng, W., Sukchawalit, R., Nakane, A., Tasaka, S., & Asano, K. (2023). Differential proteomic analysis and pathogenic effects of outer membrane vesicles derived from Acinetobacter baumannii under normoxia and hypoxia. PloS one, 18(3), e0283109. https://doi.org/10.1371/journal.pone.0283109
6. Fauzia, K. A., Aftab, H., Tshibangu-Kabamba, E., Alfaray, R. I., Saruuljavkhlan, B., Cimuanga-Mukanya, A., Matsumoto, T., Subsomwong, P., Akada, J., Miftahussurur, M., & Yamaoka, Y. (2023). Mutations Related to Antibiotics Resistance in Helicobacter pylori Clinical Isolates from Bangladesh. Antibiotics (Basel, Switzerland), 12(2), 279. https://doi.org/10.3390/antibiotics12020279
7. Hoshi, K., Kikuchi, H., Narita, K., Fukutoku, Y., Asari, T., Miyazawa, K., Murai, Y., Sawada, Y., Tatsuta, T., Hasui, K., Hiraga, H., Chinda, D., Mikami, T., Subsomwong, P., Asano, K., Nakane, A., Fukuda, S., & Sakuraba, H. (2023). Bacterial exposure risk to the endoscopist's face while performing endoscopy. DEN open, 3(1), e209. https://doi.org/10.1002/deo2.209
8. Watabe, N., Tonuma Y., Ozaki, M., Ishizawa, S., Kamata, Y., Nakane, A. (2023). Adhesion and growth of Bacillus cereus on cotton towels after forearm wiping. Journal of Japan academy of nursing science, 43, 270-279. (in Japanese), https//doi.org/10.5630/jans.43.270
2022年
1. Narita, K., Asano, K., Yamane, K., Ohashi, H., Igarashi, T., & Nakane, A. Effect of ultraviolet C emitted from KrCl excimer lamp with or without bandpass filter to mouse epidermis. PloS one, 17(5), e0267957. https://doi.org/10.1371/journal.pone.0267957 : 03 May 2022
2. Subsomwong, P., Doohan, D., Fauzia, K. A., Akada, J., Matsumoto, T., Yee, T. T., Htet, K., Waskito, L. A., Tuan, V. P., Uchida, T., Matsuhisa, T., & Yamaoka, Y. Next-Generation Sequencing-Based Study of Helicobacter pylori Isolates from Myanmar and Their Susceptibility to Antibiotics. Microorganisms, 10(1), 196. https://doi.org/10.3390/microorganisms10010196 : 17 January 2022
3. Hirose, S., Asano, K., Harada, S., Takahashi, T., Kondou., E., Ito, K., Iddamalgoda, A., Nakane ,A. Effects of salmon cartilage proteoglycan on obesity in mice fed with a high-fat diet. Food science and nutrition, 10(2), 577-583. https://doi.org.10.1002/fsn3.2685 : 20 December 2021
2021年
1. Asano K, Hirose S, Narita K, Subsomwong P, Kawai N, Sukchawalit R, Nakane A. Extracellular vesicles from methicillin resistant Staphylococcus aureus stimulate proinflammatory cytokine production and trigger IgE-mediated hypersensitivity: Extracellular vesicles of Staphylococcus aureus and host immune response. OPEN ACCESS, Emerging Microbes & Infections 10(1): 2000-2009, Accepted Author Version Posted Online: 08 Oct 2021
2. Sato'o Y, Omoe K, Aikawa Y, Kano M, Ono HK, Hu D-L, Nakane A, Sugai M. Investigation of Staphylococcus aureus positive for Staphylococcal enterotoxin S and T genes. J Vet Med Sci 83(7): 1120-1127, 2021. doi:10. 1292/jvms.20-0662
3. Akada J, Tshibangu-Kabamba E, Tuan VP, Kurogi S, Matsuo Y, Ansari S, Doohan D, Phuc BH, Subsomwong P, Waskito LA, Binh TT, Nguyen LT, Khien VV, Dung HDQ, Miftahussurur M, Syam AF, Tshering L, Vilaichone RK, Mahachai V, Ratanachu-Ek T, Shrestha PK, Yee TT, Htet K, Aftab H, Matsuhisa T, Uchida T, Okimoto T, Mizukami K, Kodama M, Murakami K, Takahashi N, Yamaoka Y. Serum Helicobacter pylori antibody reactivity in seven Asian countries using an automated latex aggregation turbidity assay. J Gastroenterol Hepatol. 2021 Aug;36(8):2198-2209. doi: 10.1111/jgh.15467. Epub 2021 Mar 9. PMID: 33609333
4. Kinoshita-Daitoku R, Kiga K, Miyakoshi M, Otsubo R, Ogura Y, Sanada T, Bo Z, Phuoc TV, Okano T, Iida T, Yokomori R, Kuroda E, Hirukawa S, Tanaka M, Sood A, Subsomwong P, Ashida H, Binh TT, Nguyen LT, Van KV, Ho DQD, Nakai K, Suzuki T, Yamaoka Y, Hayashi T, Mimuro H. A bacterial small RNA regulates the adaptation of Helicobacter pylori to the host environment. Nat Commun. 2021 Apr 9;12(1):2085. doi: 10.1038/s41467-021-22317-7. PMID: 33837194 Free PMC article.
5. Miftahussurur M, Doohan D, Syam AF, Nusi IA, Subsomwong P, Waskito LA, Maulahela H, Akil F, Uwan WB, Siregar G, Fauzia KA, Rezkitha YAA, Rahman A, Wibawa IDN, Saudale AMJ, Richardo M, Sugihartono T, Chomariyati A, Bramantoro T, Uchida T, Yamaoka Y. CYP2C19 Polymorphisms in Indonesia: Comparison among Ethnicities and the Association with Clinical Outcomes. Biology (Basel). 2021 Apr 6;10(4):300. doi: 10.3390/biology10040300. PMID: 33917299 Free PMC article.
6. Ono H-K, Suzuki Y, Kubota H, Asano K, Takai S, Nakane A, Hu D-L. Complete genome sequence of Staphylococcus aureus strain 834, isolated from a septic patient in Japan. Microbiology Resource Announcements 10(9)e01477-20,2021. https://mra.asm.org/content/10/9/e01477-20
7. Takahashi T, Ito K, Iddamalgoda A, Asano K, Nakane A. Skin-moisturizing effect of an oral supplement containing salmon nasal cartilage proteoglycan -A randomized, double blind, parallel-group, placebo-controlled study. Jpn Pharmacol Ther 49(3): 449-458, 2021.
2020年
1. Suzuki Y, Ono HK, Shimojima Y, Kubota H, Kato R, Kakuda T, Hirose S, Hu D-L, Nakane A, Takai S, Sadamasu K. A novel staphylococcal enterotoxin SE02 involved in a staphylococcal food poisoning outbreak that occurred in Tokyo in 2004. Food Microbiol 92:103568, 2020. https://doi.org/10.1016/j.fm.2020.103588
2. Masumi A, Oba Y, Tonosaki M, Aizu I, Asano K, Nakane A. Thiazolidinediones downregulate PPARγ expression via induction of aP2 during mouse 3T3-L1 preadipocyte differentiation. BPB Rep 3(4): 119-125, 2020.
3. Narita K, Asano K, Naito K, Ohashi H, Sasaki M, Morimoto Y, Igarashi T, Nakane A. Ultraviolet C light with wavelength of 222 nm inactivates a wide spectrum of microbial pathogens. J Hosp Infect 150(3): 459-467,2020. https://doi.org/10.1016/j.jhin.2020.03.030
4. Aziz F, Hisatsune J, Yu L, Kajimura J, Sato’o Y, Ono HK, Masuda K, Yamaoka M, Salasia SIO, Nakane A, Ohge H, Kusunoki Y, Sugai M. Staphylococcus aureus isolated from skin from atopic-dermatitis patients produces staphylococcal enterotoxin Y, which predominantly induces T-cell receptor Vα-specific expansion of T cells. Infect Immun 88(2): e00360-19, 2020. https://doi: 10.1128/IAI.00360-19
2019年
1. Ono HK, Hirose S, Narita K, Sugiyama M, Asano K, Hu D-L, Nakane A. Histamine release from intestinal mast cells induced by staphylococcal enterotoxin A (SEA) evokes vomiting reflex in common marmoset. PLoS Pathog 15(5): e1007803. https://doi.org/10.1371/ journal.ppat.1007803
2. Tanaka N, Hiraga H, Sakuraba H, Murai Y, Maeda T, Watanabe R, Ota S, Akemoto Y, Hasui K, Yoshida S, Asano K, Nakane A, Fukuda S. Vitamin A deficiency impairs resistance to Listeria monocytogenes infection through excessive apoptosis of macrophages. Hirosaki Med J 69(1-4):163-171, 2019.
3. Fang R, Cui J, Cui T, Guo H, Ono HK, Park C-H, Okamura M, Nakane A, Hu D-L. Staphylococcal enterotoxin C is an important virulence factor for mastitis. Toxins 11(3): 141, 2019. doi:10.3390/toxins11030141
2018年
1. Ono HK, Hachiya N, Suzuki Y, Naito I, Hirose S, Asano K, Omoe K, Nakane A, Hu DL. Development of an Immunoassay for Detection of Staphylococcal Enterotoxin-Like J, A Non-Characterized Toxin. Toxins (Basel). 6;10(11). 2018. pii: E458. doi: 10.3390/toxins10110458.
2. Asano K, Narita K, Hirose S, Nakane A. Contribution of toxic shock syndrome toxin-1 to systemic inflammation investigated by a mouse model of cervicovaginal infection with Staphylococcus aureus. Med Microbiol Immunol. 207(5-6):297-306. 2018. doi: 10.1007/s00430-018-0551-4.
3. Ono HK, Yoshimura S, Hirose S, Narita K, Tsuboi M, Asano K, Nakane A. Salmon cartilage proteoglycan attenuates allergic responses in mouse model of papain‑induced respiratory inflammation. Mol Med Rep.18(4):4058-4064. 2018. doi: 10.3892/mmr.2018.9364.
4. Narita K, Asano K, Morimoto Y, Igarashi T, Nakane A. Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses. PLoS One. 25;13(7):e0201259. 2018. doi: 10.1371/journal.pone.0201259.
5. Hirose S, Narita K, Asano K, Nakane A. Salmon cartilage proteoglycan promotes the healing process of Staphylococcus aureus-infected wound. Heliyon 4 e00587, 2018. https://doi.org/10.1016/j.heliyon.2018.e00587
6. Asano K, Takahashi E, Yoshimura S, Nakane A. Oral administration of salmon cartilage proteoglycan extends the survival of allografts in mice. Biomed Rep J 8(1):37-40. 2018. doi: 10.3892/br.2017.1011.
7. Narita K, Asano K, Morimoto Y, Igarashi T, Hamblin MR, Dai T, Nakane A. Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds. Biosci Biotechnol Biochem 81(7):1369-78, 2017. http://dx.doi.org/10.1080/09168451.2017.1318695 J Photochem Photobiol B 178:10-18. 2018. doi: 10.1016/j.jphotobiol.2017.10.030.
2017年
1. Sano M, Shang Y, Nakane A, Saito T. Salmon nasal cartilage proteoglycan enhances growth of normal human dermal fibroblast through Erk1/2 phosphorylation. Biosci Biotechnol Biochem 81(7):1369-78, 2017. http://dx.doi.org/10.1080/09168451.2017.1318695
2. Hu D-L, Ono HK, Isayama S, Okada R, Okamura M, Lei LC, Liu ZS, Zhang X-C, Liu MY, Cui JC, Nakane A. Biological characteristics of staphylococcal enterotoxin Q and its potential risk for food poisoning. J Appl Microbiol 122(6)1672-79, 2017. 6 doi:10.1111/jam.13462
3. Narita K, Asano K, Nakane A. IL-17A plays an important role in protection induced by vaccination with fibronectin-binding domain of fibronectin-binding protein A against Staphylococcus aureus infection. Med Microbiol Immunol 296(3)225-234, 2017. 5DOI 10.1007/s00430-017-0499-9
4. Ono HK, Hirose S, Naito I, Sato’o Y, Asano K, Hu D-L, Omoe K, Nakane A. The emetic activity of staphylococcal enterotoxins, SEK, SEL, SEM, SEN and SEO in a small emetic animal model, the house musk shrew. Microbiol Immunol 61(1):12-6, 2017. Doi: 10.1111/1348-0421.12460,
5. Hirose S, Asano K, Nakane A. Attenuation of obesity-induced inflammation in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent. Biochem Biophys Res Commun 484(3):480-5, 2017. http://dx.doi.org/10.1016/j.bbrc.2017.01.056
6. Asano K, Nakane A. Interplay between autophagy and pathogenic bacteria: Toxins secreted by Staphylococcus aureus and their impact on autophagy. Horosaki Med J 67(2-4):115-28, 2017.
7. Itabashi T, Narita K, Ono A, Wada K, Tanaka T, Kumagai G, Yamauchi R, Nakane A, Ishibashi Y. Bactericidal and antimicrobial effects of pure titanium and titanium alloy treated with short-time, low-energy UV irradiation. Bone Joint Res 6(2)108, 2017. doi:10.1302/20463758.62.2000619
2016年
1. Hirose S, Ono HK, Omoe k, Hu D-L, Asano K, Yamamoto Y, Nakane A. Goblet cells are involved in translocation of staphylococcal enterotoxin A in the intestinal tissue of house musk shrew (Suncus murinus). J Appl Microbiol 120(3):781-9, 2016. DOI: 10.1111/jam.13029
2. Asano K, Sashinami H, Osanai A, Hirose S, Ono HK, Narita K, Hu DL, Nakane A. Passive immunization with anti-ActA and anti-listeriolysin O antibodies protects against Listeria monocytogenes infection in mice. Sci Rep 6:39628, 2016. DOI: 10:1038/srep39628
2015年
1. Sato'o Y, Hisatsune J, Nagasako Y, Ono HK, Omoe K, and Sugai M. Positive regulation of staphylococcal enterotoxin H by Rot (repressor of toxin) protein and its importance in clonal complex 81 subtype 1 linage-related food poisoning. Appl Environ Microbiol 81(22):7782-7790, 2015.
2. Ono HK, Sato'o Y, Narita K, Naito I, Hirose S, Hisatsune J, Asano K, Hu DL, Omoe K, Sugai M, and Nakane A. Identification and characterization of a novel staphylococcal emetic toxin. Appl Environ Microbiol 81(20):7034-7040, 2015.
3. Asano K, Yoshimura S, and Nakane A. Adipose tissue-derived mesenchymal stem cells attenuate staphylococcal enterotoxin A-induced toxic shock. Infect Immun 83(9):3490-3496, 2015.
4. Narita K, Hu DL, Asano K, Nakane A. Vaccination with non-toxic mutant toxic shock syndrome toxin-1 induces IL-17-dependent protection against Staphylococcus aureus infection. Pathog Dis 73(4), pii: ftv023, 2015.
2014年
1. Asano K, Asano Y, Ono HK, and Nakane A. Suppression of starvation-induced autophagy by recombinant toxic shock syndrome toxin-1 in epithelial cells. Plos one 9(11):e113018, 2014.
2. Sato’o Y, Omoe K, Naito I, Ono HK, Nakane A, Sugai M, Yamagishi N, and Hu D-L. Molecular epidemiology and identification of a Staphylococcus aureus clone causing food poisoning outbreaks in Japan. J Clin Microbiol 52(7):2637-2740, 2014.
3. Yoshimura S, Asano K, and Nakane A. Attenuation of collagen-induced arthritis in mice by salmon proteoglycan. BioMed Res Int 2014:ID406453, 2014. http://dx.doi.org/10.1155/2014/406453
4. Hu D-L and Nakane A. Mechanism of staphylococcal enterotoxin-induced emesis. Eur J Pharmacol 722(1):95-107, 2014.
2013年
1. Omoe, K., Hu, D.-L., Ono, H.K., Shimizu, S., Takahashi-Omoe, H., Nakane, A., Uchiyama, T., Shinagawa, K., Imanishi, K. Emetic Potentials of Newly Identified Staphylococcal Enterotoxin-like Toxins. Infect Immun
2. Feng M-H, Cui J-C, Nakane A, and Hu D-L. Vaccination with plasmid DNA encoding a mutant toxic shock syndrome toxin-1 ameliorates toxin-induced lethal shock in mice. Tohoku J Exp Med 231(1):1-9, 2013.
3. Asano, K., Yoshimura, S., Nakane, A. Alteration of intestinal microbiota in mice orally administered with salmon cartilage proteoglycan, a prophylactic agent. PLoS One 8(9):e75008.
4. Kawakami, J., Kakinami, H., Matsushima, N., Nakane, A., Kitahara, H., Nagaki, M., Ito, S. Structure-activity relationship analysis for antimicrobial activities of tryptanthrin derivatives using quantum chemical calculations. J Comput Chem Jpn 12(2):109-112.
5. Sakamoto, Y, Narita, K., Nakane, A. Reduced IL-1b production in diet-induced obese mice impairs host defense against skin Staphylococcus aureus infection. Hirosaki Med J 64(1):29-40.
6. Osanai, A., Li, S.-J., Asano, K., Sashinami, H., Hu, D.-L., Nakane, A. Fibronectin-binding protein, FbpA, is the adhesion responsible for pathogenesis of
7. Sato'o, Y., Omoe., K., Ono, H.K., Nakane, A., Hu, D.-L. A novel comprehensive analysis method for Staphylococcus aureus pathogenicity islands. Microbiol Immunol 57(2):91-99.
2012年
1. Abe, Y., Hu, D.-L., Omoe, K., Fukuda, I., Nakane, A. Comparative prevalence of antibiotic resistance, staphylococcal cassette chromosome mec and superantigenic toxin genes in coagulase-negative Staphylococci. Hirosaki Med J 63(2-4), 2012.
2. Sashinami, H., Asano, K., Yoshimura, S., Mori, F., Wakabayashi, K., Nakane, A. Salmon proteoglycan suppresses progression of mouse experimental autoimmune encephalomyelitis via regulation of Th17 and Foxp3+ regulatory T cells. Lif Sci 91(25-26):1263-1269, 2012.
3. Osanai, A., Hu, D.-L., Nakane, A. Caenorhabditis elegans avoids staphylococcal superantigen toxins via 5-hydroxytryptamine-dependent pathway. Can J Microbiol 58(11):1268-1277, 2012.
4. Maina, E.-K., Hu, D.-L., Asano, K., Nakane, A. Inhibition of emetic and superantigenic activities of staphylococcal enterotoxin A by synthetic peptides. Peptides 38(1):1-7, 2012.
5. Asano, K., Kakizaki, I., Nakane, A. Interaction of Listeria monocytogenes autolysin amidase with glycosaminoglycans promotes listerial adhesion to mouse hepatocytes. Biochimie 94(6):1291-1299, 2012.
6. Ono, H.K., Nishizawa, M., Yamamoto, Y., Hu, D.-L., Nakane, A., Shinagawa, K., Omoe, K. Submucosal mast cells in the gastrointestinal tract are a target of staphylococcal enterotoxin type A. FEMS Immunol Med Microbiol 64(3):392-402, 2012.
7. Maina, E.-K., Hu, D.-L., Tsuji, T., Omoe, K., Nakane, A. Staphylococcal enterotoxin A ha potent superantigenic and emetic activities but not diarrheagenic activity. Int J Med M icrobiol 302(2):88-95,2012.
8. Shime, H., Matsumoto, M., Oshiumi, H., Tanaka, S., Nakane, A., Iwakura, Y., Tahara, H., Inoue, N., Seya, T. Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors. Proc Natl Acad Sci USA 109(6):2066-2071,2012.
9. Kubo, N., Narumi, S., Kijima, H., Mizukami, H., Yagihashi, S., Hakamada, K., Nakane, A . Efficacy of adipose tissue-derived mesenchymal stem cells for fulminant hepatitis in mi ce induced by Concanavalin A. J Gastroenterol Hepatol 27(1):165-172,2012.
2011年
1. Kawakami, J., Matsushima, N., Ogawa, Y., Kakinami, H., Nakane, A., Kitahara, H., Naga i, M., Ito, S. Antibacterial and antifungal activities of tryptanthrin derivatives. Trans ctions of the Materials Research Society of Japan 36(4):603-606,2011.
2. Hu, D-L., Maina, EK., Omoe, K., Inoue, F., Yasujima, M., Nakane, A. Superantigenic to in genes coexist with specific staphylococcal cassette chromosome mec genes in methicilli -resistant Staphylococcus aureus. Tohoku J Exp Med 225(3):161-169,2011.
3. Asano, K., Sashinami, H., Osanai, A., Asano, Y., Nakane, A. Autolysin amidase of List ria monocytogenes promotes efficient colonization of mouse hepatocytes and enhances host mmune response. Int J Med Microbiol 301(6):480-487,2011.
4. Nagaki, M., Narita, T., Ichikawa, H., Kawakami, J., Nakane, A. Antibacterial and anti ungal activities of isoprenoids. Transactions of the Materials Research Society of Japan 6(1):55-58,2011.
5. Li, S.-J., Hu, D.-L., Miana, EK., Shinagawa, K., Omoe, K., and Nakane, A. Superantite ic activity of toxic shock syndrome toxin-1 is resistant to heating and digestive enzymes J Appl Microbiol 110(3):729-736,2011.
6. Osanai, A., Sashinami, H., Asano, K., Li, S.-J., Hu, D.-L., and Nakane, A. Mouse pept doglycan recongnition protein PGLYRP-1 plays a role in the host innate immune response ag inst Listeria monocytogenes infection. Infect Immun 79(2):858-866,2011.
2010年
1. Kawakami, J., Harada, I., Nakane, A., Kitahara, H., Nagaki, M., and Ito, S. Antibacterial activity of radical compounds with peripheral quaternary ammonium units. Transact Materials Soc Jpn 35(4):885-887,2010.
2. Mitsui, T., Sashinami, H., Sato, F., Kijima, H., Ishiguro, Y., Fukuda, S., Yoshihara, S., Hakamada, K., and Nakane. A., Salmon cartilage proteoglycan supresses mouse experimen al colitis through induction of Foxp3＋reguratory T cell. Biochem Biophys Res Commun 402( ):209-215,2010
3. Omoe,K., Nunomura, W., Kato, H., Li, Z.-J., Igarasi, O., Araake, M., Sano, K., Ono, H ., Abe, Y., Hu, D.-L., Nakane, A., Kiyono, H., Takakura, H., Y, Shinagawa., K, Uchiyama., and T, Imanishi,KI., High affinity of interaction between superantigen and TCRVβ molecules induces a high level and prolonged expansion of superantigen-reactive CD4＋Tcells. J Biol Chem 285(40):30427-30435,2010
4. Narita, K., Hu, D.-L., Mori, F., Wakabayashi, K., Iwakura, Y., and Nakane, A. Role of interleukin-17A in cell-mediated protection against Staphylococcus aureus infection in mi e immunized with the fibrinogen-binding domain of clumping factor A. Infect. Immun. 78(10 ):4234-4242, 2010.
5. Sashinami, H., HU, D.-l., Li, S.-J., Mitsui, T., Hakamada, K.-I., Ishiguro, Y., Fukud , S., and Nakane, A. Virulence factor p60 of Listeria monocytegenes moduratesinnate immun ty by inducing tumor necroisis factor α. FEMS Immunol Med Micorobiol 59(1):100-107, 2010.
6. Niikura, M., Kamiya, S,. Nakane, A., Kita, K., and Kobayashi, F. IL-10 plays a crucia role for the protection of experimental cerebral malaria by co-infection with non-lethal malaria parasites. Int J Parasitol 40(1): 101-108, 2010.
7. Kudo, K., Liu, Y., Takahashi, K., Tarusawa, K., Osanai, M., Hu, D.-L., Kashiwakura, I , Kijima, H., and Nakane, A. Transplantation of mesenchymal stem cells to prevent radiati n-induced intestinal injury in mice. J. Radiat. Res. 51(1): 73-79. 2010.
8. Sashinami, H., and Nakane, A. Adiponectin is required for enhancement of CCL2 express on in adipose tissue during Listeria monocytogenes infection. Cytokine 50(2): 170-174, 20 0.
9. Cui, J.-C., Zhang, B.-J., Wang, Q.-K., Qian, A.-D., Lin, Yan.-C., Hu, D.-L., Nakane, ., and Tong, G.-Z. Protective effect of glutathione S-transferase-fused mutant staphyloco cal enterotoxin C against Staphylococcus aureus-induced bovine mastitis. Vet. Immun. Immu nopath. 135 (5): 64-70. 2010.
2009年
1. Hu, D.-L., Omoe, K., Sashinami, H., Shinagawa, K., and Nakane, A. Immunization with a nontoxic mutant of staphylococcal enterotoxin A, SEA D227A, protects against enterotoxin-induced emesis in house musk shrews. J. Infect. Dis. 199(3): 302-310. 2009.
2. Liu, Y., Kudo, K., Abe, Y., Hu, D.-L., Kijima, H., Nakane,A., and Ono, K. Inhibition f transforming growth factor-β, hypoxia inducible factor-1α and vascular endothelial gr wth factor reduced late rectal injury induced by irradiation. J. Radiat. Res. 50(3): 233- 239. 2009.
3. Hu, D.-L., Narita, K., Hyodo, M., Hayakawa, Y., Nakane, A., and Karaolis, DKR. c-di-G P as vaccine adjuvant enhances protection against systemic methicillin-resistant Staphylo occus aureus (MRSA) infection. Vaccine 27(35): 4867-4873. 2009.
4. Satoh, Y., Ishiguro, Y., sakuraba, H., Kawaguchi, S., Hiraga, H., Fukuda, S., and Nakane, A. Cyclosporine regulates intestinal epithelial apoptosis via TGF-β-related signalin . Am. J. Physiol. Gastrointest. Liver Physiol. 297(3): G514-519. 2009.
5. Osanai, A., Harada, S., Sakamoto, K., Shimizu, H., Inaoka, DK., and Kita, K. Crystall zation of mitochondrial rhodoquinol-fumarate reductase from the parasitic nematode Ascari suum with the specific inhibitor flutolanil. Acta Cryst. F65(9): 941-944. 2009.
6. Zhang, B.-J., Cui,J.-C., Zhang, X., Qian, A.-D., Tong, G.-Z., Hu, D.-L., Nakane, A., nd Wang, Q.-K. Development and evaluation of Staphylococcus aureus-induced mastitis model Chn. J. Prev. Vet. Med. 31(5): 365-369, 2009.
7. Zhang, B.-J., Cui, J.-C., Zhang, X., Lin, Y.-C., Qian, A.-D., Tong, G.-Z., Hu, D.-L., Nakane, A., and Wang, Q.-K. Immunization with glutathione S-transferase-fused mutant stap ylococcal enterotoxin C protects against Staphylococcus aureus-induced mastitis in mouse model. Chn. J. Prev. Vet. Med. 31(7): 557-562, 2009.
2008年
1. Narita, K., Hu, D.-L., Tsuji, T., and Nakane, A. Intranasal immunization of mutant to ic shock syndrome toxin 1 elicits systemic and mucosal immune response against Staphyloco cus aureus infection. FEMS Immunol. Med. Microbiol. 52(3):389-396. 2008.
2. Narita, K., Hu, D.-L., Tsuji, T., and Nakane, A. Protective effect of intranasal vacc nation with notoxic mutant toxic shock syndrome toxin 1 against Staphylococcus aureus inf ctions. Hirosaki Med. J. 59(2-4):71-82. 2008.
3. Liu, Y., Kudo, K., Abe, Y., Aoki, M., Hu, D.-L., Kijima, H., and Nakane, A. Hypoxia e pression in radiation-induced late rectal injury. J. Radiat. Res. 49(3):261-268. 2008.
4. Ono, H., Omoe, K., Imanishi, K., Iwakabe, Y., Hu, D.-L., Kato, H., Saito, N., Nakane, A., Uchiyama, T., and Shinagawa, K. Identification and characterization of two novel stap hylococcal enterotoxins, types S and T. Infect. Immun. 76(11):4999-5005, 2008.
5. Hu, D.-L., Omoe, K., Inoue, F., Kasai, T., Yasujima, M., Shinagawa, K., and Nakane, A Comparative prevalence of superantigenic toxin genes in methicillin-resistant and methic llin-susceptible Staphylococcus aureus islates. J. Med. Microbiol. 57(9):1106-1112, 2008.
2007年
1. Sato, F., Imaizumi, T., Sashinami, H., Yoshida, H., Kusumi, T., Mori, F., Wakabayashi K., Nakane, A., Satoh, K., and Kijima, H. Upregulation of vascular endothelial growth fa ctor by heat-killed Listeria monocytogenes in macrophages. Biochem. Biophys. Res. Commun. 354(2):608-612. 2007.
2. Liu, Y., Nakahara, T., Miyakoshi, J., Hu, D.-L., Nakane, A., and Abe, Y. Nuclear accu ulation and activation of nuclear factor κB after split-dose irradiation in LS174T cells J. Radiat. Res. 48(1):13-20. 2007.
3. Imaizumi, T., Yoshida, H., Nishi, N., Sashinami, H., Nakamura, T., Hirashima, M., Ohy ma, C., Itoh, K., and Satoh, K. Double-stranded RNA induces galectin-9 in vascular endoth elial cells: involvement of TLR3, PI3K and IRF3 pathway. Glycobiology 17(7):12C-5C. 2007.
4. Kudo, K., Abe, Y., Hu, D.-L., and Nakane, A. Colonization and differentiation of tran lanted embryonic stem cells in the irradiated intestine of mice. Tohoku J. Exp. Med. 212 (2):143-150. 2007.
5. Hu, D.-L., Zhu, G., Mori, F., Omoe, K., Okada, M., Wakabayashi, K., Kaneko, S., Shina awa, K., and Nakane, A. Staphylococcal enterotoxin induces emesis through increasing serotonin release in intestine and it is downregulated by cannabinoid receptor 1. Cell. Microb iol. 9(9):2267-2277. 2007.
2006年
1. Sato, H., Suzuki, K., Osanai, A., Kamiya, H., and Furuoka, H. Identification and characterization of threadworm, Strongyloides procyonis, from feral raccoons (Procyon lotor) in Japan. J. Parasitol. 92(1):63-68. 2006.
2. Nigawara, T., Iwasaki, Y., Asai, M., Yoshida, M., Kanbayashi, M., Sashinami, H., Hashimoto, K., and Suda, T. Inhibition of 11β-hydroxysteroid dehydrogenase eliminates impaire glucocorticoid suppression and induces apoptosis in corticotroph tumor cells. Endocrinology 147(2):769-772. 2006.
3. Sashinami, H., Yamamoto, T., and Nakane, A. The cytokine balance in the maintenance o a persistent infection with Salmonella enterica serovar Typhimurium in mice. Cytokine 33 4):212-218. 2006.
4. Sasaki, S., Tagawa, Y., Iwakura, Y. , and Nakane, A. The role of gamma interferon in cquired host resistance against Staphylococcus aureus infection in mice . FEMS Immunol. M d. Microbiol. 46(3):367-374. 2006.
5. Sashinami, H., Sakuraba, H. Ishiguro, Y., Munakata, A., Nishihira, J., and Nakane, A. The role of macrophage migration inhibitory factor in lethal Listeria monocytogenes infection in mice. Microb. Pathog. 4(2-3):111-118. 2006.
6. Ishiguro, Y., Ohkawa, T., Sakuraba, H., Yamagata, K., Hiraga, H., Yamaguchi, S., Fuku a, S., Munakata, A., Nakane, A., and Nishihira, J. Macrophage migration inhibitory factor has a proinflammatory actibity via the p38 pathway in glucocorticoid-resistant ulcerative colitis. Clin. Immunol. 120(3):335-341. 2006.
7. Imaizumi, T., Sashinami, H., Mori, F., Matsumiya, T., Yoshida, H., Nakane, A., Wakabayashi, K., Oyama, C., and Satoh, K. Listeria monocytogenes induces the expression of retin ic acid-inducible gene-I. ;Microbiol. Immunol. 50(10):811-815. 2006.
8. Sashinami, H., Takagaki, K., and Nakane, A. Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages. Biochem. Biophys. Res. Commun. 351(4):1005-1010. 2006.
9. Hu, D.-L., Omoe, K., Narita, K., Cui, J.-C., Shinagawa, K., and Nakane, A. Intranasal vaccination with a double mutant of staphylococcal enterotoxin C provides protection against Staphylococcus aureus infection. Microbes Infect. 8(14-15):2841-2848. 2006.
10. Sato, H., Suzuki, K., Osanai, A., and Aoki, M. Paragonimus westermani and some rare i testinal trematodes recovered from raccoon dogs (Nyctereutes procyonoides viverrinus) int oduced recently on Yakushima Island, Japan. J. Vet. Med. Sci. 68(7):681-687. 2006.
11. Arita, M., Suematsu, T., Osanai, A., Inaba T, Kamiya, H., Kita. K., Sisido, M., Watanabe, Y.,and Ohtsuki, T. An evolutionary 'intermediate state' of mitochondrial translation ystems found in Trichinella species of parasitic nematodes: co-evolution of tRNA and EF-T . Nucleic Acid Res. 34(18):5291-5299. 2006.
2005年
1. Ikejima, S., Sasaki, S., Sashinami, H., Mori, F., Ogawa, Y., Nakamura, T., Abe, Y., Wakabayashi, K., Suda, T. , and Nakane, A. Impairment of host resistance to Listeria monocytogenes infection in liver of db/db and ob/ob mice . Diabetes 54(1):182-189. 2005.
2. 　Tanabe, M., Matsumoto, T., Shibuya, K., Tateda, K., Miyazaki, S., Nakane, A., Iwakura Y., and Yamaguchi, K. Compensatory response of IL-1 gene knockout mice after pulmonary infection with Klebsiella pneumoniae. J. Med. Microbiol. 54(1):7-13. 2005.
3. Wakabayashi, T., Hu, D.-L., Tagawa, Y., Sekikawa, K., Iwakura, Y., Hanada, K., and Nakane, A. IFN-γ and TNF-α are involved in urushiol-induced contact hypersensitivity in mice. Immunol. Cell. Biol. 83(1):18-24. 2005.
4. Hu, D.-L., Cui, J.-C., Omoe, K., Sashinami, H., Yokomizo, Y., Shinagawa, K. , and Nakane, A. A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection .Infect. Immun. 73(1):174-180. 2005.
5. Cui, J.-C., Hu, D.-L., Lin, Y.-C., Qian, A.-D. , and Nakane, A. Immunization with glu athione S-transferase and mutant toxic shock syndrome toxin 1 fusion protein protects aga inst Staphylococcus aureus infection . FEMS Immunol. Med. Microbiol. 45(1):45-51. 2005.
6. Omoe, K., Hu, D.-L., Takahashi-Omoe, H., Nakane, A., and Shinagawa, K. Comprehensive analys s of classical and newly described staphylococcal superantigenic toxin genes in Staphylococcus aureus isolates. FEMS Lett. 246(2):191-198. 2005.
7. Sato, H., Osanai, A., Kamiya, H., Obara, Y., Jiang, W., Zhen, Q., Chai, J., Une, Y. , and Ito, M. Characterization of SSU and LSU rRNA genes of three Trypanosoma (Herpetosoma) grosi isolates maintained in Mongolian jirds . Parasitology 130(Pt2):157-167. 2005.
8. Horino, T., Matsumoto, T., Uramatsu, M., Tanabe, M., Tateda, K., Miyazaki, S., Nakane, A.,Iwakura, Y., and Yamaguchi, K. Interleukin-1-deficient mice exhibit high sensitivity to gut-derived sepsis caused by Pseudomonas aeruginosa. Cytokine 30(6):339-346. 2005.
9. Sato, H., Osanai, A., Kamiya, H. , and Une, Y. Gizzard spirurid nematode Acuaria skrjabinin Japanese tree sparrows and a gray starling from Tokyo . J. Vet. Med. Sci. 67(6):607-609. 2005.
10. Omoe, K., Imanishi, K., Hu, D.-L., Kato, H., Fugane, Y., Abe, Y., Hamaoka, S., Watanabe, Y. Nakane, A., Uchiyama, T., and Shinagawa, K. Characterization of novel staphylococcal enterotoxin-like toxin type P. Infect. Immun. 73(9):5540-5546. 2005.
11. Hu, D.-L., Suga, S., Omoe, K., Abe, Y., Shinagawa, K., Wakui, M., and Nakane, A. Staphylococcal enterotoxin A modulates intracellular Ca2+ signal pathway in human intestinal epithelial cells. FEBS Lett. 579(20):4407-4412. 2005.
12. Inaoka, DK., Takashima, E., Osanai, A., Shimizu, H., Nara, T., Aoki, T., Harada, S. , and Kita, K. Expression, purification and crystallization of Trypanosoma cruzi dihydroorotate dehydrogenase complexed with orotate . Acta. Crystallograph. Sect. F. Struct. Biol. Cryst. Commun. 61(Pt 10):875-878. 2005.
13. Sashinami, H., Kageyama, K., Suda, T., and Nakane, A. Urocortin 2 suppresses host resistanc to Listeria monocytogenes infection via up-regulation of interleukin-10 . Endocrinology 146(11):5003-5011. 2005.
2004年
1. Chisty, MM., Nargis, M., Inaba, T., Ishita, K., Osanai, A., and Kamiya, H. Transmission electron microscopy of Schistosoma mansoni cercariae treated with hinokitiol (beta-thujaplicin), a compound for potential skin application against cercaria penetration. Tohoku J. Exp. Med. 202(1):63-67. 2004.
2. Widiashih, D.-A., Matsuda, I., Omoe, K., Hu. D.-L., Sugii, S., and Shinagawa, K. Passive transfer of antibodies to Shig a toxin-producing Escherichia coli O26, O111 and O157 antigens in neonatal calves by feeding colostrum. J. Vet. Med. Sci. 66 2):213-215. 2004.
3. Yamashita, T., Ino, T., Miyoshi, H., Sakamoto, K., Osanai, A., Nakamaru-Ogiso, E. , and Kita, K. Rhodoquinone reaction ite of mitochondrial complex I, in parasitic helminth, Ascaris suum . Biochim. Biophys. Acta. 1608(2-3):97-103. 2004.
4. Hasegawa, S., Nishikawa, S., Miura, T., Saito, Y., Madarame, H., Sekikawa, K., Tagawa, Y.-I., Iwakura, Y., and Nakane, A. Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis in mice. Microb. Pathog. 37(3):119-12. 2004.
5. Sato, H., Ishita, K., Osanai, A., Yagisawa, M., Kamiya, H. , and Ito, M. T cell-dependent elimination of dividing Trypa osoma grosi from the bloodstream of Mongolian jirds . Parasitology 128(Pt3):295-304. 2004.
6. Sato, H., Matsuo, K., Osanai, A., Kamiya, H., Akao, N., Owaki, S. , and Furuoka, H. Larva migrans by Baylisascaris tran fuga: fatal neurological diseases in Mongolian jirds, but not in mice . J. Parasitol. 90(4):774-781. 2004.
7. Omoe, K., Imanishi, K., Hu, D.-L., Kato, H., Takahashi-Omoe, H., Nakane, A., Uchiyama, T. , and Shinagawa, K. Biologica properties of staphylococcal enterotoxin-like toxin type R . Infect. Immun. 72(6):3664-3667. 2004.
8. Mikami, T., Satoh, N., Hatayama, I., and Nakane, A. Buthionine sulfoximine inhibits cytophathic effect and apoptosis in uced by infection with human echovirus 9. Arch. Virol. 149(6):1117-1128. 2004.
2003年
1. Sashinami, H., Nakane, A., Iwakura, Y. , and Sasaki, M. Effective induction of acquired resistance to Listeria monocytogenes by immunizing mice with in vivo-infected dendritic cells . Infect. Immun. 71(1):117-125. 2003.
2. Nihei, C., Fukai, Y., Kawai, K., Osanai, A., Yabu, Y., Suzuki, T., Ohta, N., Minagawa, N., Nagai, K., and Kita, K. Purification of active recombinant trypanosome alternative oxidase. FEBS Lett. 538(1-3):35-40. 2003.
3. Takaya, A., Suzuki, M., Matsui, H., Tomoyasu, T., Sashinami, H., Nakane, A. , and Yamamoto, T. Lon, a stress-induced ATP-dependent protease, is critically important for systemic Salmonella enterica serovar typhimurium infection of mice . Infect. Immun. 71(2):690-696. 2003.
4. Hu, D.-L., Omoe, K., Simada, Y., Nakane, A. , and Shinagawa, K. Induction of emetic response to staphylococcal enterotoxins in the house musk shrew (Suncus murinus) . Infect. Immun. 71(2):690-696. 2003.
5. Amino, H., Osanai, A., Miyadera, H., Shinjyo, N., Tomitsuka, E., Taka, H., Mineki, R., Murayama, K., Takamiya, S., Aoki, T., Miyoshi, H., Sakamoto, K., Kojima, S. , and Kita, K. Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria . Mol. Biochem. Parasitol. 128(2):175-186. 2003.
6. Miyadera, H., Shiomi, K., Ui, H., Yamaguchi, Y., Masuma, R., Tomoda, H., Miyoshi, H., Osanai, A., Kita, K. , and Omura, S. Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase) . Proc. Natl. Acad. Sci. USA 100(2):473-477. 2003.
7. Kamiya, H., Inaba, T., Sato, H. , and Osanai, A. A red fox, Vulpes vulpes shrencki, infected with Echinococcus multilocularis was introduced from Hokkaido Island, where E. multilocularis is endemic, to Aomori, northern part of the mainland Japan . Jpn. J. Infect. Dis. 56(4):180-181. 2003.
8. Hu, D.-L., Omoe, K., Sasaki, S., Sashinami, H., Sakuraba, H., Yokomizo, Y., Shinagawa, K., and Nakane, A. Vaccination with nontoxic mutant toxic shock syndrome toxin 1 protects against Staphylococcus aureus infection. J. Infect. Dis. 188(5):743-752. 2003.
9. Omoe, K., Hu, D.-L., Takahashi-Omoe, H., Nakane, A. , and Shinagawa, K. Identification and characterization of a new staphylococcal enterotoxin-related putative toxin encoded by two kinds of plasmids . Infect. Immun. 71(10):6088-6094. 2003.
2002年
1. Sasaki, S., Omoe, K., Tagawa, Y., Iwakura, Y., Sekikawa, K., Shinagawa, K., and Nakane, A. Roles of gamma interferon and tumor necrosis factor-alpha in shiga toxin lethality. Microb. Pathog. 33(1):43-47. 2002.
2. Hasegawa, S., Miura, T., Sasaki, S., Madarame, H., and Nakane, A. Dysregulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphoplastic aly mutant mice. FEMS Immunol. Med. Microbiol. 32(2):111-117. 2002.
3. Takashima, E., Inaoka, DK., Osanai, A., Nara, T., Odaka, M., Aoki, T., Inaka, K., Harada, S., and Kita, K. Characterization of the dihydroorotate dehydrogenase as a soluble fumarate reductase in Trypanosoma cruzi. Mol. Biochem. Parasitol. 122(2):189-200. 2002.
4. Diao, H., Kohanawa, M., Yimin, Nakajima, H., Sato, Y., Minagawa, T., and Nakane, A. Lipopolyaccharide triggers invasive streptococcal disease in mice through a tumour necrosis factor-α-dependent mechanism. Immunology 105(3):344-349. 2002.
5. Omoe, K., Ishikawa, M., Shimada, Y., Hu, D.-L., Ueda, S., and Shinagawa, K. Detection of seg, she, and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin: Productivities of S. aureus isolates haboring seg, she, or sei genes. J. Clin. Microbiol. 40(3):857-862. 2002.
6. Mizuki, M., Nakane, A., Sekikawa, K., Tagawa, Y. , and Iwakura, Y. Comparison of host resistance to primary and secondary Listeria monocytogenes infections in mice by intranasal and intravenous routes . Infect. Immun. 70(9):4805-4811. 2002.
7. Kakizaki, I., Takagaki, K., Endo, Y., Kudo, D., Ikeya, H., Miyoshi, T., Baggenstoss, B. A., Tlapak-Simmons, V. L., Kumari, K., Nakane, A., Weigel, P. H., and Endo, M. Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone. Eur. J. Biochem. 269(20):5066-5075. 2002.
2001年
1. Mizuki, D., Miura, T., Sasaki, S., Mizuki, M., Madarame, H., and Nakane, A. Interference between host resistance to Listeria monocytogenes infection and ovalbumin-induced allergic responses in mice. Infect. Immun. 69(3):1883-1888. 2001.
2. Hu, D.-L., Omoe, K., Saleh, M.-H., Ono, K., Sugii, S., Nakane, A., and Shinagawa, K. Analysis of the epitopes on staphylococcal enterotxin A responsible for emetic activity. J. Vet. Med. Sci. 63(3):237-241. 2001.
3. Yamamoto, T., Sashinami, H., Takaya, A., Tomoyasu, T., Matsui, H., Kikuchi, Y., Hanawa, T., Kamiya, S. , and Nakane, A. Disruption of the genes for ClpXP protease in Salmonella enterica serovar Typhimurium results in persistent infection in mice, and development of persistence requires endogenous gamma interferon and tumor necrosis factor alpha . Infect. Immun. 69(5):3164-3174. 2001.
4. Miura, T., Kudo, T., Matsuki, A., Sekikawa, K., Tagawa, Y., Iwakura, Y., and Nakane, A. Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection. Infect. Immun. 69(12):7234-7241. 2001.
2000年
1. Yamada, K., Yoshino, K., Sekikawa, K., Madarame, H., Yagita, H., and Nakane, A. Effect of a matrix metalloproteinase inhibitor on host resistance against Listeria monocytogenes infection. FEMS Immunol. Med. Microbiol. 29(3):187-194. 2000.
2. Shinagawa, K., Kanehira, M., Omoe, K., Matsuda, I., Hu, D.-L., Widiasih, D. A., and Sugii, S. Frequency of Shiga toxin-producing Escherichia coli in cattle at a breeding farm and at a slaughterhouse in Japan. Vet. Microbiol. 76(3):305-309. 2000.
3. Miura, T., Nishikawa, S., Sasaki, S., Yamada, Y., Hasegawa, S., Mizuki, D., Mizuki, M., Hatayama, I., Sekikawa, Y., Tagawa, Y., Iwaura, Y., and Nakane, A. Roles of endogenous cytokines in liver apoptosis of mice in lethal Listeria monocytogenes infection. FEMS Immunol. Med. Microbiol. 28(4):335-341. 2000.
4. Sasaki, S., Nishikawa, S., Miura, T., Mizuki, M., Yamada, K., Madarame, H., Tagawa, Y.-I., Iwakura, Y., and Nakane, A. Interleukin-4 and interleukin-10 are involved in host resistance to Staphylococcus aureus infection through regulaiton of gamma interferon. Infect. Immune. 68(5):2424-2430. 2000.
5. Miura, T., Mizuki, D., Sasaki, S., Hasegawa, S., Sashinami, H. , and Nakane, A. Host resistance to Listeria monocytogenes infection is enhanced but resistance to Staphylococcus aureus infection is reduced in acute graft-versus-host disease in mice . Infect. Immun. 68(7):4340-4343. 2000.
1999年
1. Kasuga-Aoki, H., Takai, S., Sasaki, Y., Tsubaki, S., Madarame, H., and Nakane, A. Tumour necrosis factor alpha and interferon-gamma are required in host resistance against virulent Rhodococcus equi infection in mice: cytokine production depends on the virulence levels of R. equi. Immunology 96(1):122-127. 1999.
2. Nakane, A., Yamada, K., Hasegawa, S., Mizuki, D., Mizuki, M., Sasaki, S., and Miura, T. Endogenous cytokines during a lethal infection with Listeria monocytogenes in mice. FEMS Microbiol. Lett. 175(1):133-142. 1999.
3. Hu, D.-L., Omoe, K., Nakane, A., Sugii, S., Ono, K., Sasaki, S., and Shinagawa, K. Studies on the functional site on staphylococcal enterotoxin A responsible for production of murine gamma interferon. FEMS Immunol. Med. Microbiol. 25(3):237-244. 1999.
4. Lan, D. T. B., Makino, S., Shirahata, T., Yamada, M., and Nakane, A. Tumor necrosis factor alpha and gamma interferon are required for the development of protective immunity to secondary Corynebacterium pseudotuberculosis infection in mice. J. Vet. Med. Sci. 61(11):1203-1208. 1999.
5. Hu, D.-L., Omoe, K., Shimura, H., Ono, K., Sugii, S., and Shinagawa, K. Emesis in the shrew mouse (Suncus murinus) induced by peroral and intraperitoneal administration of staphylococcal enterotoxin A. J. Food Prot. 62(11):1350-1353. 1999.
6. Lan, D. T. B., Makino, S., Shirahata, T., Yamada, M., and Nakane, A. Complement receptor type 3 plays an important role in development of protective immunity to primary and secondary Corynebacterium pseudotuberculosis infection in mice. Microbiol. Immunol. 43(12):1103-1106. 1999.
1998年
1. Nakane, A., Asano, M., Miura, T., Sasaki, S., Nishikawa, S., Kohanawa, M., and Minagawa, T. Neuropeptides in the livers of mice during bacterial infections. FEMS Immunol. Med. Microbiol. 20(2):159-164. 1998.
2. Nishikawa, S., , and Nakane, A. Host resistance against Listeria monocytogenes is reciprocal during the course of infection in alymphoplastic aly mutant mice. Cell. Immunol. 187(2):88-94. 1998.
3. Sasaki, S., Miura, T., Nishikawa, S., Yamada, K., Hirasue, M., and Nakane, A. Protective role of nitric oxide in Staphylococcus aureus infection in mice. Infect. Immun. 66(3):1017-1022. 1998.
4. Nishikawa, S., Hirasue, M., Miura, T., Yamada, K., Sasaki, S., and Nakane, A. Systemic dissemination by intrarectal infection with Listeria monocytogenes in mice. Microbiol. Immunol. 42(4):325-327. 1998.
5. Hu, D.-L., Imai, A., Ono, K., Sasaki, S., Nakane, A., Sugii, S., and Shinagawa, K. Epitope analysis of staphylococcal enterotoxin A using different synthetic peptides. J. Vet. Med. Sci. 60(9):993-996. 1998.
6. Lan, D. T. B., Taniguchi, S., Makino, S., Shirahata, T., and Nakane, A. Role of endogenous tumor necrosis factor alpha and gamma interferon in resistance to Corynebacterium pseudotuberculosis infection in mice. Microbiol. Immunol. 42(12):863-870. 1998.
1997年
1. Kohanawa, M., Asano, M., Minagawa, T., and Nakane, A. Macrophage antigen-1 positive cells are essential in the defense against Theiler's virus strain GD VII infection in the spinal cord. Microb. Pathog. 23(1):33-38. 1997.
2. Madarame, H., Takai, S., Matsumoto, C., Minamiyama, K., Sasaki, Y., Tsubaki, S., Hasegawa, Y., and Nakane, A. Virulent and avirulent Rhodococcus equi infection in T-cell deficient athymic nude mice: pathologic, bacteriologic and immunologic responses. FEMS Immunol. Med. Microbiol. 17(4):251-262. 1997.
1996年
1. Nishikawa, S., Miura, T., Sasaki, S., and Nakane, A. The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice. FEMS Immunol. Med. Microbiol. 16(3):291-298. 1996.
2. Nakane, A., Nishikawa, S., Sasaki, S., Miura, T., Asano, M., Kohanawa, M., Ishikawa, K., and Minagawa, T. Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in gamma interferon-depleted mice. Infect. Immun. 64(4):1252-1258. 1996.
3. Isogai, E., Isogai, H., Kimura, K., Hayashi, S., Kubota, T., Nishikawa, T., Nakane, A., and Fujii, N. Cytokines in the serum and brain in mice infected with distinct species of Lyme disease Borrelia. Microb. Pathog. 21(6):413-419. 1996.
4. Asano, M., Kohanawa, M., Minagawa, T., and Nakane, A. Reciprocal action of interferon-gamma and interleukin-4 promotes granulomatous inflammation induced by Rhodococcus aurantiacus in mice. Immunology 88(7):394-399. 1996.
5. Nakane, A., Asano, M., Sasaki, S., Nishikawa, S., Miura, T., Kohanawa, M., and Minagawa, T. Transforming growth factor alpha is protective in host resistance against Listeria monocytogenes infection in mice. Infect. Immun. 64(9):3901-3904. 1996.
6. Shinagawa, K., Ueno, Y., Hu, D.-L., Ueda, S., and Sugii, S. Mouse lethal activity of a HEp-2 vacuolation factor, cereulide, produced by Bacillus cereus isolated from vomiting-type food poisoning. J. Vet. Med. Sci. 58(10):1027-1029. 1996.
1995年
1. Tamura, M., Nakajima, Y., Omura, T., Ito, K., Kimura, J., Kusumoto, K., Isai, H., Uchino, J., Nakane, A., and Minagawa, T. Can anti-Mac-1 and anti-TNF monoclonal antibody protect the liver from warm ischemia-reperfusion injury in mice?. Transplant Proc. 27(1):768-770. 1995.
2. Kohanawa, M., Nakane, A., Asano, M., and Minagawa, T. CD3+/TCR-αβ cells are important in protecting spiral cord tissues against Theiler's virus strain GDVII infection. Microbiol. Immunol. 39(2):123-128. 1995.
3. Takai, S., Madarame, H., Matsumoto, C., Inoue, M., Sasaki, Y., Hasegawa, Y., Tsubaki, S., and Nakane, A. Pathogenesis of Rhodococcus equi infection in mice: roles of virulence plasmids and granulomagenic activity of bacteria. FEMS Immunol. Med. Microbiol. 11(3):181-190. 1995.
4. Nakane, A., Okamoto, M., Asano, M., Kohanawa, M. , and Minagawa, T. Endogenous gamma interferon, tumor necrosis factor, and interleukin-6 in Staphylococcus aureus infection in mice . Infect. Immun. 63(4):1165-1172. 1995.
5. Nakne, A., Nishikawa, S., Sasaki, S., Miura, T., Asano, M., Kohanawa, M., and Minagawa, T. A monoclonal antibody against T-cell receptor γδ induces endogenous cytokines and prevents mice from a lethal infection with Listeria monocytogenes. FEMS Immnol. Med. Microbiol. 11(4):321-327. 1995.
6. Asano, M., Nakane, A., Kohanawa, M., and Minagawa, T. Sequential involvement of NK cells and CD8+ T cells in granuloma formation of Rhodococcus aurantiacus-infected mice. Microbiol. Immunol. 39(7):499-507. 1995.
7. Kohanawa, M., Asano, M., YiMin, Minagawa, T., and Nakane, A. Paralysis caused by acute myelitis in Theiler's murine encephalomyelitis virus strain GD VII infection is induced by CD4+ lymphocytes infiltrating the spinal cord. J. Gen. Virol. 76(9):2251-2256. 1995.
1994年
1. Kohanawa, M., Nakane, A., Asano, M., and Minagawa, T. Theiler's virus is eliminated by a gamma-interferon-independent mechanism in the brain. J. Neuroimmunol. 52(1):79-86. 1994.
2. Nakane, A., Okamoto, M., Asano, M., Kohanawa, M., Satoh, Y., and Minagawa, T. Protection by dexamethasone from a lethal infection with Listeria monocytogenes in mice. FEMS Immunol. Med. Microbiol. 9(2):163-170. 1994.
3. Sirahata, T., Shimoi, A., Kanda, H., Goto, H., and Nakane, A. Importance of early gamma interferon production in Propionibacterium acnes-induced resistance to Toxoplasma gondii infection in mice. J. Vet. Med. Sci. 56(2):293-297. 1994.
4. Tsutsumi, K., Kagaya, Y., Hidaka, S., Suzuki, J., Tokairin, Y., Hirai, T., Hu, D.-L., Ishikawa, K., and Ejiri, S. Structural analysis of the chloroplastic and cytoplasmic aldolase-encoding genes implicated the occurrence of multiple loci in rice. Gene 141(2):215-220. 1994.
5. Yamashita, T., Nakane, A., Watanabe, T., Miyoshi, I., and Kasai, N. Evidence that alpha-fetoprotein suppresses the immunological function in transgenic mice. Biochem. Biophys. Res. Commun. 201(3):1154-1159. 1994.
6. Okamoto, M., Nakane, A., and Minagawa, T. Host resistance to an intragastric infection with Listeria monocytogenes in mice depends on cellular immunity and intestinal bacterial flora. Infect. Immune. 62(8):3080-3085. 1994.
7. Shirahata, T., Yamashita, T., Ohta, C., Goto, H., and Nakane, A. CD8+ T lymphocytes are the major cell population involved in the early gamma interferon response and resistance to acute primary Toxoplasma gondii infection in mice. Microbiol. Immunol. 38(10):789-796. 1994.
8. Zhu, X., Imamura, M., Tanaka, J., W Han, C., Hashino, S., Imai, K., Asano, M., Nakane, A., Minagawa, T., Kobayashi, M., Sakuraba, K., and Miyazaki, T. Effects of 15-deoxyspergualin in vitro and in vivo on cytokine gene expression. Transplantation 58(10):1104-1109. 1994.

研究実績

2025年

2024年

2023年

2022年

2021年

2020年

2019年

2018年

2017年

2016年

2015年

2014年

2013年

2012年

2011年

2010年

2009年

2008年

2007年

2006年

2005年

2004年

2003年

2002年

2001年

2000年

1999年

1998年

1997年

1996年

1995年

1994年