弘前大学 大学院医学研究科 / 医学部医学科

Staffs

• Associate professor: Tadashi Yoshizawa
• Assistant professor: Shintaro Goto
• Assistant: Kenta Ogasawara

Outline

A．Bioscience and Physiological Pathology
Functional analyses in various diseases, using procedures of molecular biology, cell biology and physiological pathology. Improvement of basic and diagnostic pathology.

B．Tumor Pathology
Biological/morphological analyses of tumor growth, differentiation and metastasis of human cancer, using procedures of molecular biology, histopathology and immunohistochemistry. Pathogenesis and physiological pathology of human tumor cells. Improvement of basic and diagnostic pathology.

Research Aims

• A．Bioscience and Physiological Pathology

  　Functional analyses in various diseases, using procedures of molecular biology, cell biology and physiological pathology. Analyses of molecular mechanisms of circadian rhythm. Improvement of basic and diagnostic pathology.

• B．Tumor Pathology

  　Biological/morphological analyses of tumor growth, differentiation and metastasis of human cancer, using procedures of molecular biology, histopathology and immunohistochemistry. Pathogenesis and physiological pathology of human tumor cells. Improvement of basic and diagnostic pathology.　Analysis of the relationship between clinical imaging data and histopathology and predictors of response to chemotherapy.

Current Research Topics

• A．Bioscience and Physiological Pathology
  1. Molecular and pathophysiological analyses of neurogenesis in cancer tissue
  2. Molecular and cell biological mechanisms of angiogenesis.
  3. Molecular and cell biological mechanisms of carcinogenesis, cell growth and differentiation.
  4. Molecular and cell biological mechanisms of anti-cancer therapy (e.g. chemotherapy).
• B．Tumor Pathology
  1. Histopathological analyses of pancreato-biliary cancer: regulation/suppression of tumor growth, differentiation and metastasis; Diagnostic pathology of pancreato-biliary cancer.
  2. Histopathological analyses of gastrointestinal cancer: suppression of tumor growth, and apoptosis induction; Diagnostic pathology of gastrointestinal cancer (esophageal, gastric and colorectal cancers).
  3. Histopathological analyses of breast cancer: regulation/suppression of tumor growth, differentiation and metastasis; Histological evaluation for therapeutic effects of breast cancer.
  4. Investigation of predictors of treatment efficacy using clinical imaging data and pathology
  5. Three-dimensional image analysis of cancer using Tissue clearing method.