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Endocrinology and Metabolism内分泌代謝内科学講座

Staffs

  • Professor: Yukihiro Fujita
  • Associate Professor: Shinobu Takayasu, Miyuki Yanagimachi
  • Lecturer: Jutaro Tanabe
  • Lecturer (Hospital affiliation): Yuki Matsuhashi, Kota Matsuki
  • Assistant Professor: Tsuyoshi Yanagimachi, Shingo Murasawa, Sho Osonoi, Saturu Mizushiri, Tomoyuki Fujita, Kiho Hamaura, Shoma Ono
  • Research Associate: Mari Usutani

Educational program

  • 1. Trainees are requested to have fruitful expertise as a clinical expert and/or an established researcher who can pursue new findings from clinical cases. Trainees can learn clinical statistics and data analysis methods through big cohorts, observational, or intentional studies.
  • 2. Trainees can learn experimental techniques in vitro and in vivo (animal experiments, tissue culturing, molecular biology, gene expression analysis, western blotting, immunohistochemistry, radioisotope experiments, and assays (eg. ELISA)) to gain new insights into diabetes, metabolic, and endocrine diseases.
  • 3. Trainees are encouraged to publish case reports or original articles from their experienced cases or basic research with vigorous investigations.
  • 4. Trainees are encouraged to expand their research in domestic and international outstanding laboratories.

Research program

<Basic Research>

  • 1. Secretion and physiological actions of incretin, especially short-form GIP.
  • 2. Physiological effects and biological activities of oxyntomodulin, a glucagon-related peptide.
  • 3. Biology of proglucagon-producing cells.
  • 4. Ketone bodies in the small intestine, nutrient signaling and systemic metabolic regulation.
  • 5. Mechanistic analysis in glucocorticoid receptor gene mutations.
  • 6. Regulatory mechanism of pro-opiomelanocortin gene expression in ACTH-producing cells.
  • 7. Investigation of Glucocorticoid Resistance Mechanisms in ACTH-Producing Pituitary Tumors.
  • 8. The Role of Vasopressin Co-expressed in Hypothalamic CRF Neurons.
  • 9. Brain Distribution, Neural Projections, and Functional Roles of Urocortin.
  • 10. Measurement of cholesterol efflux by HDL and identification of its regulating factors.

<Clinical Research>

  • 1. Changes in pancreatic function and nutritional status after pancreatectomy.
  • 2. Investigation of appropriate blood glucose management for pancreatogenic diabetes mellitus (Type 3B diabetes).
  • 3. Relationship between diabetes treatment and resting energy metabolism.
  • 4. Clinical differentiation between ACTH-dependent Cushing syndrome and pseudo-Cushing syndrome.
  • 5. Investigation of early diagnosis of pituitary dysfunction by immune checkpoint inhibitors.
  • 6. Development of diagnostic methods for subclinical hypopituitarism.
  • 7. The relationship between periodontal disease and diabetes mellitus.
  • 8. Clinical evaluation of diabetic neuropathy using simple testing devices.
  • 9. Long-term fluctuation of HDL cholesterol levels in the Aomori residence and its contributing factors.
  • 10. Global epidemiologic analysis of glucagon and related peptides.

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