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Neuroanatomy, Cell Biology and Histology神経解剖・細胞組織学講座

Staffs

  • Professor (Anatomical Science): Hiroshi Shimoda
  • Lecturer: Yoshiya Asano
  • Assistant professor: Erina Saito
  • Assistant: Daisuke Okano

The faculty of Neuroanatomy / Cell Histology, together with the faculty of Biostructure Medical Science, is based on anatomical / morphological science, which explores the structure / function and development of tissues and organs, as the basis of education and research. In order to study all organs of the living body and the pathophysiology, we are trying to elucidate the "universe of the living body" by various approaches such as medical biology and engineering in addition to anatomical research.

Current researchs

  • ◆ Molecular and morphological research on lymphatic vessels
    • To find the answer to "what are lymphatic vessels?" we are studying the lymphatic structure and development, mechanisms and therapeutic strategies of lymphatic cancer metastasis and lymphedema, using histochemical and molecular morphological techniques.

      ・Molecular morphological analysis of the functional construction and formation mechanism of the microcirculatory system centered on lymphatic vessels

      ・Molecular morphological study of lymphatic vessel development / neoplasia mechanism

      ・Analysis of lymphatic vessel development and structure / function using fish models

      ・Molecular morphological analysis of cancer lymphangiogenesis and metastasis mechanism

      ・Development of lymphangiogenesis system as a treatment strategy for lymphedema
  • ◆ Development and medical application of functional 3D biological tissues
    • In order to establish new research models and medical applications, we are conducting research on the development and application of functional three-dimensional biological tissues including vascular / lymphatic networks and nervous networks using the cell accumulation method. Furthermore, we are developing artificial peritoneal tissue and applying to the research on pathophysiology and treatment as the cancer peritoneal dissemination models.

      ・Analysis of angiogenetic mechanism combining artificial 3D tissue containing vascular / lymphatic network and imaging technology

      ・Research on the construction of artificial nerve tissue with vasculature and the formation of neuron networks

      ・Construction of artificial vascular tissue using mesenchymal stem cells and endothelial precursor cells for application to regenerative medicine

      ・Basic research on lymphedema treatment by transplantation of artificial lymphatic network tissue

      ・Study of cancer peritoneal dissemination pathology and drug effect using artificial peritoneal tissue with vascular and lymphatic networks
  • ◆ Ultrastructural analysis using electron microscopy
    • Using scanning electron microscopy (SEM) and transmission electron microscopy (TEM), we perform ultrastructural analysis of tissues and cultured cells of various organisms such as humans, mice, and fish, as well as engineered artificial tissues. We also use analytical electron microscopy to perform qualitative and quantitative analysis of elements and elemental distribution analysis in microregions.
  • ◆ Tissue non-heme iron distribution and tissue injury by oxidative stress
    • Using highly sensitive non-heme ferric iron and non-heme ferrous iron staining methods, we are visualizing iron accumulation in aging and disease at the tissue or cellular level, and studying its relationship to pathological conditions such as oxidative stress injury.

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