弘前大学 大学院医学研究科 / 医学部医学科

Staffs

• Professor: Hirofumi Tomita
• Associate professor: Shingo Sasaki
• Lecturer: Takeshi Fujita
• Lecturer (hospital affiliation): Kenji Hanada
• Assistant professor:　Takahiko Kinjo,　Ikuyo Kinjo, Michiko Tsushima　

Outline

　We have 2 groups for patient care and research: Cardiology, and Nephrology. To clarify the pathogenesis of cardiovascular diseases and renal diseases and to create new diagnostic procedures and therapies, 2 groups are performing together the following research projects. Each group also has each specific education program to generate an excellent physician scientist.

A. Cardiology

Research projects

• 1. Clinical and experimental studies on atherosclerosis
• 2. Investigation for pathogenesis of coronary artery spasm
• 3. Experimental study on the pathogenesis of the hypertensive cardiovascular diseases
• 4. Clinical and experimental studies on remote monitoring system using implant device in patients with heart diseases
• 5. Clinical and experimental studies on the pathogenesis of congestive heart failure
• 6. Clinical and experimental studies on the pathogenesis of supraventricular and ventricular tachyarrhythmias and atrial fibrillation
• 7. Clinical studies on the effect of direct oral anticoagulants (DOAC) in patients with non-valvular atrial fibrillation
• 8. Imaging studies on the coronary plaque lesion in patients with ischemic heart diseases

Education program

• 1. Clinical and experimental procedures to achieve the clarification of pathogenesis, upgrade of diagnostic methods, and development of new therapy for cardiovascular diseases
• 2. Molecular biological procedures such as generation of transgenic mouse
• 3. Molecular and biochemical experiments such as PCR and Western blotting and so on
• 4. Clinical procedures for cardiac catheterization and electrophysiology

B. Nephrology

Research projects

• 1. Study on generation of extracellular matrix and chemokine in human cultured mesangial cells, proximal tubular epithelial cells, and podocyte cells
• 2. Clinical study on metabolism of lipid and fatty acids in kidney diseases
• 3. Study on the effect of n-3 fatty acids on experimental nephritis

Education program

• 1. Procedure of cell culture, measurement of extracellular matrix-regulating factors and chemokines, and understanding the pathogenesis of kidney disease
• 2. Procedure of measurement of lipid and fatty acids in the plasma of the kidney disease patients, and investigation of their involvement in the pathogenesis
• 3. Investigation of n-3 fatty acids as a novel therapeutic strategy using experimental nephritis