留学レポート - 弘前大学大学院医学研究科泌尿器科学講座

留学者

濱野逸人

留学先

Sanford Burnham Perbys Medical Discovery Institute, La Jolla, CA 92037, USA. Yu Yamaguchi Lab

研究テーマ
- プロテオグライカンについて
- 前立腺癌とヒアルロン酸について
留学期間

2018年1月～

留学レポート
- 留学レポート No.1 2018/7/12
発表論文
- Onco-testicular sperm extraction (Onco-TESE) from a single testis with metachronous bilateral testicular cancer: a case report.
  Hamano I, Hatakeyama S, Nakamura R, Fukuhara R, Noro D, Seino H, Yoneyama T, Hashimoto Y, Koie T, Yokoyama Y, Ohyama C.
  Basic Clin Androl. 2018 Jan 25;28:1. doi: 10.1186/s12610-018-0066-2
- Differences in semen characteristics between patients with testicular cancer and other malignancies using various cut-off values.
  Hamano I, Hatakeyama S, Nakamura R, Fukuhara R, Noro D, Tanaka T, Yoneyama T, Yamamoto H, Yoneyama T, Hashimoto Y, Koie T, Yokoyama Y, Ohyama C.
  Int J Urol. 2018 Sep;25(9):817-824. doi: 10.1111/iju.13732.
- Condyloma Acuminata of the Urethra in a Male Renal Transplant Recipient: A Case Report.
  Hamano I, Hatakeyama S, Yamamoto H, Fujita T, Murakami R, Shimada M, Imai A, Yoneyama T, Yoneyama T, Hashimoto Y, Koie T, Narumi S, Saitoh H, Suzuki T, Tomita H, Ohyama C.
  Transplant Proc. 2018 Oct;50(8):2553-2557. doi: 10.1016/j.transproceed.2018.02.182.

留学者

山本勇人

留学先

Sanford Burnham Perbys Medical Discovery Institute, La Jolla, CA 92037, USA. Yu Yamaguchi Lab

研究テーマ
- プロテオグライカンについて
- 前立腺癌とヒアルロン酸について
留学期間

2015年1月～2017年6月

留学レポート
- 留学レポート No.1 2015/12/7
発表論文
- TMEM2: A missing link in hyaluronan catabolism identified?
  Yamaguchi Y, Yamamoto H, Tobisawa Y, Irie F.
  Matrix Biol. 2018 Mar 27. pii: S0945-053X(17)30476-6. doi: 10.1016/j.matbio.2018.03.020.
- A mammalian homolog of the zebrafish transmembrane protein 2 (TMEM2) is the long-sought-after cell-surface hyaluronidase.
  Yamamoto H, Tobisawa Y, Inubushi T, Irie F, Ohyama C, Yamaguchi Y.
  J Biol Chem. 2017 May 5;292(18):7304-7313. doi: 10.1074/jbc.M116.770149

留学者

畠山真吾

留学先

The Burnham Institute, La Jolla, CA 92037, USA. Michiko Fukuda Lab

研究テーマ
- 精子の運動、癌標的療法、化学合成
留学期間

2006年10月～2008年9月

留学レポート
発表論文
- Tumor targeting by a carbohydrate ligand-mimicking peptide.
  Hatakeyama S, Shibata TK, Tobisawa Y, Ohyama C, Sugihara K, Fukuda MN.
  Methods Mol Biol. 2013;1022:369-86. doi: 10.1007/978-1-62703-465-4_28.
- Attenuation of fibroblast growth factor signaling by poly-N-acetyllactosamine type glycans.
  Sugihara K, Shibata TK, Takata K, Kimura T, Kanayama N, Williams R, Hatakeyama S, Akama TO, Kuo CW, Khoo KH, Fukuda MN.
  FEBS Lett. 2013 Oct 1;587(19):3195-201. doi: 10.1016/j.febslet.2013.07.056.
- Enhancement of mouse sperm motility by trophinin-binding peptide.
  Park SK, Yoon J, Wang L, Shibata TK, Motamedchaboki K, Shim KJ, Chang MS, Lee SH, Tamura N, Hatakeyama S, Nadano D, Sugihara K, Fukuda MN.
  Reprod Biol Endocrinol. 2012 Nov 29;10:101. doi: 10.1186/1477-7827-10-101.
- Carbohydrate mimetic peptides as research reagent and therapeutic.
  Fukuda MN, Hatakeyama S, Sugihara K.
  Biol Pharm Bull. 2012;35(10):1626-32. Review.
- Targeted drug delivery to tumor vasculature by a carbohydrate mimetic peptide.
  Hatakeyama S, Sugihara K, Shibata TK, Nakayama J, Akama TO, Tamura N, Wong SM, Bobkov AA, Takano Y, Ohyama C, Fukuda M, Fukuda MN.
  Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19587-92. doi: 10.1073/pnas.1105057108. Epub 2011 Nov 23.
- Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes.I Immunity 2010
- Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase.
  Bao X, Kobayashi M, Hatakeyama S, Angata K, Gullberg D, Nakayama J, Fukuda MN, Fukuda M.
  Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12109-14. doi: 10.1073/pnas.0904515106.
- Core3 O-glycan synthase suppresses tumor formation and metastasis of prostate carcinoma PC3 and LNCaP cells through down-regulation of alpha2beta1 integrin complex.
  Lee SH, Hatakeyama S, Yu SY, Bao X, Ohyama C, Khoo KH, Fukuda MN, Fukuda M.
  J Biol Chem. 2009 Jun 19;284(25):17157-69. doi: 10.1074/jbc.M109.010934.
- Identification of mRNA splicing factors as the endothelial receptor for carbohydrate-dependent lung colonization of cancer cells.
  Hatakeyama S, Sugihara K, Nakayama J, Akama TO, Wong SM, Kawashima H, Zhang J, Smith DF, Ohyama C, Fukuda M, Fukuda MN.
  Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3095-100. doi: 10.1073/pnas.0810110106.
- Enhancement of human sperm motility by trophinin binding peptide.
  Hatakeyama S, Sugihara K, Lee SH, Nadano D, Nakayama J, Ohyama C, Fukuda MN.
  J Urol. 2008 Aug;180(2):767-71. doi: 10.1016/j.juro.2008.03.185. Epub 2008 Jun 13. Erratum in: J Urol. 2010 May;183(5):2102.
学会演題発表
- Annual Conference of the Society for Glycobiology Nov 2006, Los Angels, CA
  
  Carbohydrate structure of prostate-specific and its distinct affinity to Maackia amurensis lectin between cancer and non-cancer source
  
  GnT-V expression correlates with patient survival in bladder.
- Annual Conference of the Society for Glycobiology Nov 2006, Los Angels, CA
  
  Identification of novel carbohydrate binding endothelial receptors by a carbohydrate-mimicking peptide
- The 11th Annual San Diego Glycobiology symposium, Feb 2008, San Diego, CA, USA
  
  Targeting chemotherapy by carbohydrate-mimicking peptide with Geldanamycin to solid tumors
- The Annual Meeting of the AUA, May2008, Orlando, FL, USA
  
  Trophinin-binding peptide, GWRQ, promotes human sperm motility